Andre Levchenko
· John C. Malone ProfessorYale University · Biological Engineering
Active 2000–2026
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About
Andre Levchenko is the John C. Malone Professor of Biomedical Engineering at Yale University. His research focuses on systems biology, signal transduction, and cell-cell communication, with particular interests in cell decision making, microfluidics, micro- and nano-fabrication, and stem cell engineering. Levchenko has made significant contributions to understanding the dynamics of biochemical signaling networks, including MAP kinase signaling modules and NF-κB signaling, as well as intercellular transfer mechanisms mediating multidrug resistance in tumor cells. His work also explores the structural and functional regulation of cardiac tissue constructs, neuronal growth cone engineering, and the information transduction capacity of biochemical signaling networks. Throughout his career, Levchenko has been recognized with numerous awards and honors, including election as a Fellow of the American Institute for Medical and Biological Engineering, and has contributed extensively to the scientific community through publications and participation in influential conferences.
Research topics
- Biology
- Computer Science
- Cell biology
- Neuroscience
- Psychology
- Cognitive science
- Biochemistry
- Artificial Intelligence
- Genetics
- Evolutionary biology
Selected publications
Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis
Molecular Cell · 2021 · 132 citations
European Heart Journal · 2021 · 120 citations
AIMS: Mortality rates from chronic kidney disease (CKD) have increased in the last decade. In this pre-specified analysis of the DAPA-CKD trial, we determined the effects of dapagliflozin on cardiovascular and non-cardiovascular causes of death. METHODS AND RESULTS: DAPA-CKD was an international, randomized, placebo-controlled trial with a median of 2.4 years of follow-up. Eligible participants were adult patients with CKD, defined as a urinary albumin-to-creatinine ratio (UACR) 200-5000 mg/g an…
First Organoid Intelligence (OI) workshop to form an OI community
Frontiers in Artificial Intelligence · 2023 · 52 citations
The brain is arguably the most powerful computation system known. It is extremely efficient in processing large amounts of information and can discern signals from noise, adapt, and filter faulty information all while running on only 20 watts of power. The human brain's processing efficiency, progressive learning, and plasticity are unmatched by any computer system. Recent advances in stem cell technology have elevated the field of cell culture to higher levels of complexity, such as the develop…
Cell stem cell · 2025-05-01 · 23 citations
articleCas12a-knock-in mice for multiplexed genome editing, disease modelling and immune-cell engineering
Nature Biomedical Engineering · 2025-03-20 · 22 citations
articleOpen accessThe pleiotropic effects of human disease and the complex nature of gene-interaction networks require knock-in mice allowing for multiplexed gene perturbations. Here we describe a series of knock-in mice with a C57BL/6 background and with the conditional or constitutive expression of LbCas12a or of high-fidelity enhanced AsCas12a, which were inserted at the Rosa26 locus. The constitutive expression of Cas12a in the mice did not lead to discernible pathology and enabled efficient multiplexed genom…
Recent grants
Collaborative Research: Multicellular Communication in Gradient Sensing
NSF · $220k · 2015–2018
NIH · $1.8M · 2017
NIH · $8.3M · 2013
Frequent coauthors
- 120 shared
Alfredo Quiñones‐Hinojosa
Jacksonville College
- 108 shared
Hugo Guerrero-Cázares
Mayo Clinic in Florida
- 95 shared
Christopher L. Smith
University of Pennsylvania
- 82 shared
Kshitiz Gupta
University of Connecticut
- 79 shared
Kaisorn L. Chaichana
WinnMed
- 76 shared
Olindi Wijesekera
- 75 shared
Mingxin Zhu
Ocean University of China
- 71 shared
Qian Li
Labs
Yale Biomedical EngineeringPI
Awards & honors
- Computational Molecular Biology Post-Doctoral Fellowship fro…
- Invited Participant in the National Academies Inaugural Keck…
- Inaugural Distinguished Guest lecturer, Molecular and Cellul…
- Featured as an Outstanding Young Scientist in a special issu…
- American Asthma Foundation Early Excellence Award (2010)
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