Daniel Coman

About

Daniel Coman, PhD, is an Associate Professor of Radiology and Biomedical Imaging and of Biomedical Engineering at Yale School of Medicine. His research focuses on the development of molecular imaging methods to reveal physiological and chemical alterations underlying disease in preclinical models and to exploit these findings in clinical applications. He utilizes advanced Magnetic Resonance (MR) techniques, including multi-nuclear MR Spectroscopy and multi-modal MR Imaging, to conduct in vivo biomedical imaging research on both pre-clinical and clinical scanners. His primary research interest is in developing new MR imaging biomarkers for cancer, aiming to better understand resistance mechanisms and design new therapies. Notably, he developed an ultrafast MR Spectroscopic Imaging technique called Biosensor Imaging of Redundant Deviation in Shifts (BIRDS) for mapping the acidic microenvironment of cancer. His work encompasses exploring tumor microenvironments, endothelial dysfunction, and the use of high-resolution thermal imaging to delineate effects of cancer-induced aerobic glycolysis and endothelial dysfunction. Dr. Coman's research also includes investigating brain and liver neoplasms, molecular imaging, and the development of biomarkers to improve cancer diagnosis and treatment.

Research topics

• Medicine
• Internal medicine
• Biology
• Cancer research
• Materials science
• Pathology
• Chemistry
• Pharmacology
• Physiology
• Endocrinology

Selected publications

• Renal plasticity revealed through reversal of polycystic kidney disease in mice

  Nature Genetics · 2021 · 118 citations

  DOI

• Cysteine depletion triggers adipose tissue thermogenesis and weight loss

  Nature Metabolism · 2025-06-03 · 33 citations

  articleOpen access
  PublisherOA PDFDOI

• Imaging Hallmarks of the Tumor Microenvironment in Glioblastoma Progression

  Frontiers in Oncology · 2021 · 32 citations

  6.1-6.8) early and throughout progression, but U251 tumors were more acidic, suggesting lower aerobic glycolysis in U87 tumors. Characterizing these cancer hallmarks with DCE-MRI, ADC-MRI, and BIRDS-MRSI will be useful for exploring tumorigenesis as well as timely therapies targeted to specific vascular and metabolic aspects of the tumor microenvironment.

  DOI

• mTOR inhibition enhances synaptic and mitochondrial function in Alzheimer’s disease in an APOE genotype-dependent manner

  Journal of Cerebral Blood Flow & Metabolism · 2024-06-16 · 11 citations

  articleOpen access

  Apolipoprotein ε4 (APOE4) carriers develop brain metabolic dysfunctions decades before the onset of Alzheimer’s disease (AD). A goal of the study is to identify if rapamycin, an inhibitor for the mammalian target of rapamycin (mTOR) inhibitor, would enhance synaptic and mitochondrial function in asymptomatic mice with human APOE4 gene (E4FAD) before they showed metabolic deficits. A second goal is to determine whether there may be genetic-dependent responses to rapamycin when compared to mice wi…

  PublisherOA PDFDOI

• Effect of Incomplete Cryoablation and Matrix Metalloproteinase Inhibition on Intratumoral CD8⁺ T-Cell Infiltration in Murine Hepatocellular Carcinoma

  Radiology · 2024-02-01 · 10 citations

  articleOpen access

  Background Image-guided tumor ablation is the first-line therapy for early-stage hepatocellular carcinoma (HCC), with ongoing investigations into its combination with immunotherapies. Matrix metalloproteinase (MMP) inhibition demonstrates immunomodulatory potential and reduces HCC tumor growth when combined with ablative treatment. Purpose To evaluate the effect of incomplete cryoablation with or without MMP inhibition on the local immune response in residual tumors in a murine HCC model. Materi…

  PublisherDOI

Frequent coauthors

• Fahmeed Hyder

  Yale University

  173 shared

• Douglas L. Rothman

  Resonance Research (United States)

  41 shared

• Yuegao Huang

  37 shared

• Basavaraju G. Sanganahalli

  Yale University

  37 shared

• Péter Hermán

  Yale University

  30 shared

• Sandeep K. Mishra

  26 shared

• John J. Walsh

  Griffith University

  24 shared

• Samuel Maritim

  Resonance Research (United States)

  23 shared

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