Caroline Osborne

About

Caroline Osborne joined the UNC School of Law faculty in 2024, serving as the Associate Professor of Law and Director of the Kathrine R. Everett Law Library. Her teaching and research interests include copyright law, cultural property law, scholarly impact, and legal research pedagogy. She is a prolific author with work published in various law journals, and her 2023 book, Sources and Strategies of Legal Research, received the 2024 Joseph L. Andrews Legal Literature Award and the American Association of Law Libraries Academic Special Interests Section Book Award. Osborne has been recognized multiple times for her contributions to academic law librarianship, including awards from the American Association of Law Libraries and the Frederick Charles Hicks Award.

Research topics

• Internal medicine
• Medicine
• Pathology
• Oncology
• Bioinformatics
• Radiology
• Cancer research
• Cell biology
• Biology

Selected publications

• Data from Comprehensive Genomic Analysis Identifies Novel Subtypes and Targets of Triple-Negative Breast Cancer

  2023-03-31 · 1 citations

  preprintOpen access

  <div>Abstract<p><b>Purpose:</b> Genomic profiling studies suggest that triple-negative breast cancer (TNBC) is a heterogeneous disease. In this study, we sought to define TNBC subtypes and identify subtype-specific markers and targets.</p><p><b>Experimental Design:</b> RNA and DNA profiling analyses were conducted on 198 TNBC tumors [estrogen receptor (ER) negativity defined as Allred scale value ≤ 2] with >50% cellularity (discovery set: <i&…

  PublisherDOI

• Abstract PS4-02: Patient-derived Xenografts (PDX) Allow Deconvolution of Combination Chemotherapy Response

  Clinical Cancer Research · 2025-06-13

  article

  Abstract Introduction: Triple-negative breast cancer (TNBC) patients frequently receive combination chemotherapy treatment, including most recently taxane/platinum combinations. However, treatment is not biomarker-guided. As such, it is not known which patient will respond to one or the other agent, or indeed which patients actually require the combination for the most effective treatment. We hypothesized that optimization of chemotherapy may be possible if molecular mechanisms and biomarkers un…

  PublisherDOI

• Abstract P1-03-20: Role of MCM2 and the licensing complex in predicting endocrine and CDK4/6 inhibitor resistance in ER+ breast cancer

  Clinical Cancer Research · 2025-06-13

  article

  Abstract Background: Metastatic ER+/HER2- breast cancer (BC) is inevitably associated with resistance to endocrine therapy (ET) and CDK4/6 inhibitors (CDK4/6i). However, there remains a need for comprehensive understanding of resistance mechanisms and better predictive biomarkers for patient selection or new treatment strategies. We previously reported that in the NeoPalAna trial (NCT01723774), high expression of the origin licensing complex (LC) was associated with resistance to CDK4/6i and a s…

  PublisherDOI

• Supplemental Figure Legend from Phosphatase PTP4A3 Promotes Triple-Negative Breast Cancer Growth and Predicts Poor Patient Survival

  2023-03-30

  preprintOpen access

  <p>Supplemental Figure Legend</p>

  PublisherDOI

• Supplementary Figure 5 from Phosphatase PTP4A3 Promotes Triple-Negative Breast Cancer Growth and Predicts Poor Patient Survival

  2023-03-30

  preprintOpen access

  <p>Supp Fig 5 - A) PTP4A3 and Myc amplification status in Luminal A/B and Basal-like breast cancers from TCGA data set. B) PTP4A3 and Myc amplification status in ovarian cancer from TCGA data set. C) Map detailing the location of the genes analyzed for gene amplification. D) Comparative analysis of PTP4A3 gene copy number and expression levels</p>

  PublisherDOI

Recent grants

• Translational Research in Breast Cancer

  NIH · $44.7M · 2014–2026

• Baylor College of Medicine Cancer Center - Cancer Center Support Grant

  NIH · $60.1M · 2007–2030

• NIH Grant P50CA058183

  NIH · $17.3M · 2013

Frequent coauthors

• Rachel Schiff

  72 shared

• Susan G. Hilsenbeck

  Baylor College of Medicine

  69 shared

• Kathy S. Albain

  Loyola University Chicago

  54 shared

• Mothaffar F. Rimawi

  Baylor College of Medicine

  52 shared

• William E. Barlow

  Fred Hutch Cancer Center

  50 shared

• Laura F. Hutchins

  University of Arkansas for Medical Sciences

  50 shared

• Robert B. Livingston

  50 shared

• Dawn L. Hershman

  Columbia University Irving Medical Center

  49 shared

Education

• Ph.D., Law

  University of North Carolina at Chapel Hill

  2005

• Other, Law

  University of North Carolina at Chapel Hill

  2002

• B.A., Political Science

  University of North Carolina at Chapel Hill

  1999

Awards & honors

• Sources and Strategies of Legal Research won the 2024 Joseph…
• Sources and Strategies of Legal Research won the 2024 Americ…
• 2015 and 2020 winner of the American Association of Law Libr…
• 2023 recipient of the Frederick Charles Hicks Award for Outs…
• 2024 Service to SEAALL award for sustained service to the ch…

Similar researchers at University of North Carolina at Chapel Hill

• Marjorie S. Whiteh-74
• Eric Fisherh-68
• Jeffrey M. Hirschh-28