Beverly Aagaard Kienitz
· Professor (CHS)University of Wisconsin-Madison · Radiology
Active 2006–2020
About
Dr. Beverly Aagaard Kienitz is a professor (CHS) of Radiology and Neurological Surgery at the University of Wisconsin School of Medicine and Public Health. She earned her medical degree at the University of California, Davis, and completed her General Surgery internship and Radiology residency at the University of California, San Francisco. She further specialized through a Neuroradiology fellowship at the University of Washington, Seattle, and an Interventional Neuroradiology fellowship at Columbia University, New York. Dr. Kienitz is the Endovascular Neurosurgery / Interventional Neuroradiology Fellowship Program Director at the University of Wisconsin. Her clinical expertise includes adult and pediatric neuroendovascular and neurointerventional treatments of stroke, cerebral aneurysm, AVM embolization, vascular malformation sclerotherapy, tumor embolization, and intracranial/extracranial stenting.
Research topics
- Artificial Intelligence
- Medicine
- Internal medicine
- Radiology
- Nuclear medicine
- Surgery
Selected publications
Stroke · 2020
Senior authorCorresponding- Artificial Intelligence
- Medicine
- Radiology
Introduction: Time from diagnostic imaging to groin puncture highly correlates with outcome and often accounts for delays between hospital arrival and EVT. Our study comparing image quality and information content of MDCTP and CBCTP provides feasibility data for selected AIS patients to go straight to the angio-suite for comprehensive imaging and treatment. Methods: AIS patients eligible for EVT underwent MDCTP, then a CBCTP study on arrival in angio-suite. Of 939 admitted June 2017-April 2019, 226 (24%) received EVT. Of these 54 (35%) were enrolled to receive additional CBCTP imaging. Inability to obtain consent and co-morbidities were major causes for non-enrollment. Times from the start of MDCTP to angio-suite and from angio-suite arrival to first arterial image were recorded. Acquired CBCTP data were reconstructed and processed with an in-house toolbox. MDCTP and CBCTP data were matched for slice thickness and angulation and were processed using RAPID CTP (iSchemaView, Inc.). The rCBF, rCBV, MTT, tMAX maps were randomized to generate 3 unique evaluation sets. 3 neuroradiologists scored diagnostic image quality, artifacts, mismatch pattern detection and EVT indication using 5-point Likert scales. Stroke laterality was compared with the clinical standard for diagnostic accuracy. Results: Accuracies for stroke diagnosis are 97% [95%, 97%] with MDCTP and 92% [90%, 95%] with CBCTP. Cohen’s Kappa between observers is 0.90 for MDCTP-based diagnosis and 0.89 for CBCTP-based diagnosis. Scores of CBCTP to make the stroke diagnosis, detect mismatch pattern, and make treatment decision were non-inferior to corresponding scores for MDCTP (alpha=0.05) within 10% of the whole score range. Subjective scores of MDCTP for image quality and artifacts were slightly superior to those of CBCTP (1.8 vs. 2.3, p<0.01). Conclusions: In this study, a direct to angio-suite workflow provided non-inferior perfusion imaging for AIS patient triage while saving nearly one hour per patient.
Stroke · 2020
- Medicine
- Nuclear medicine
- Radiology
Cerebral perfusion evaluation using CT or MR perfusion is the gold standard modality to select large vessel occlusion (LVO) stroke patients presenting >6 hours from symptom onset. The availability of cone beam C-arm CT perfusion (CBCTP) in angiography suites could reduce time to endovascular revascularization. We aimed to evaluate the reliability of using CBCTP when compared to multidetector CT perfusion (MDCTP). In this prospective, single-arm, interventional study, 14 LVO anterior circulation thrombectomy patients underwent both a 128 slice MDCTP in the ED and a CBCTP <30 minutes apart prior to groin puncture. CBCTP was acquired using a prototype acquisition mode enabling 10 consecutive C-Arm rotations with nearly continuous data acquisition. A total of 60 cc of contrast layered with 60 cc of saline were injected covering arterial inflow, parenchymal phase and venous outflow. Image data was reconstructed into CBF, CBV, MTT and TTP maps. Three types of measurements were used to compare modalities. In measurement 1, 6 circular regions of interest (ROI) (400mm 2 ) were placed in the anterior arterial territory. In measurement 2, circular ROIs were placed in the ASPECTS regions (cortical 300mm 2 , subcortical 200mm 2 ). In measurement 3, a ROI was drawn around the entire affected area. All ROIs were placed in the basal ganglia and supraganglionic level of both brain sides. Rates (unaffected/affected area) between MDCTP and CBCTP were compared for all sequences. The intraclass correlation coefficient (ICC) was calculated using a single rater, consistency, two-way random-effects model. Measurement 1 found a moderate degree of agreement between MDCTP and CBCTP in CBF, CBV, MTT and TTP rates with ICCs of 0.58 (CI 0.42 - 0.69), 0.65 (CI 0.53 - 0.74), 0.77 (CI 0.68 - 0.83) and 0.52 (CI 0.35 - 0.65). In measurement 2, moderate agreement was found in CBF, CBV and MTT rates; with ICCs of 0.51 (CI 0.32 - 0.65), 0.57 (CI 0.4 - 0.69) and 0.62 (CI 0.47 - 0.73). The results of measurement 3 found an excellent (ICC=0.95, CI 0.88 - 0.98), good (ICC=0.83, CI 0.62 - 0.9) and moderate (ICC=0.7, CI 0.34 - 0.87), degree of agreement in the CBV, MTT and CBF rates, respectively. These results demonstrate promising accuracy of CBCTP in the evaluating ischemic tissue in patient presenting with LVO acute stroke.
Frequent coauthors
- 9 shared
David Niemann
University of Wisconsin–Madison
- 8 shared
Azam Ahmed
- 6 shared
Mark Corriveau
University of Wisconsin–Madison
- 5 shared
Sebastian Schäfer
Varian Medical Systems (Germany)
- 5 shared
Guang‐Hong Chen
University of Wisconsin–Madison
- 5 shared
Santiago Ortega‐Gutiérrez
University of Iowa Hospitals and Clinics
- 4 shared
Kelly Capel
University of Wisconsin–Madison
- 4 shared
Yiping Li
Hankou University
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