About

Bethany A. Buck is an Associate Professor of Chemistry and an Adjunct Associate Professor of Biochemistry at the University of Utah. Her research primarily focuses on utilizing a multidisciplinary approach that incorporates structural biology, biophysics, biochemistry, molecular biology, and cellular biology to explore structure-function relationships in protein/protein and protein/nucleic acid interactions. She is particularly interested in investigating methyl-CpG DNA binding proteins, which recognize methylated DNA sequences and play a key role in gene transcription regulation through chromatin remodeling and gene silencing. Her work aims to understand the mechanisms by which these proteins recognize their DNA targets and regulate transcription, especially in the context of cancer epigenetics. Her research includes structural characterization of protein-DNA interactions, evaluation of protein interaction partners, and elucidation of the molecular mechanisms underlying DNA methylation recognition and chromatin remodeling, with the goal of advancing therapeutic strategies targeting these regulatory networks.

Research topics

• Biophysics
• Biochemistry
• Chemistry

Selected publications

• DNA Damage Accelerates G-Quadruplex Folding in a Duplex-G-Quadruplex-Duplex Context

  Journal of the American Chemical Society · 2024 · 13 citations

  • Chemistry
  • Biophysics
  • Biochemistry

  -DGD constructs yielded spectral signatures that suggest the formation of G4 motifs and demonstrated a folding dependency on the nature and location of DNA damage. Importantly, the PQS folding half-lives measured are relevant to replication, transcription, and DNA repair time frames.

  DOI

Frequent coauthors

• Gianluigi Veglia

  4 shared

• Alessandro Mascioni

  ImaginAb (United States)

  2 shared

• Fernando Porcelli

  Università degli Studi della Tuscia

  2 shared

• David D. Thomas

  University of Minnesota

  1 shared

• Brandon Leonel Guerra Castañaza Jenkins

  University of Utah

  1 shared

• Tara L. Kirby

  National Institutes of Health

  1 shared

• Aaron M. Fleming

  1 shared

• Kevin Hallock

  Boston University

  1 shared

Similar researchers at University of Utah

• Teruo Okanoh-160
• Mario Capecchih-134
• Gerald J. Gleichh-119
• Michael Allen Pulsipherh-110
• Alfred K. Cheungh-106