Andrew Dillin

About

Andrew Dillin is a Howard Hughes Medical Institute Investigator and a Professor of Immunology and Molecular Medicine at the University of California, Berkeley. His research focuses on molecular and cell biology, with particular emphasis on immunology and molecular medicine. He is associated with the Department of Molecular and Cell Biology at UC Berkeley, where he conducts research and contributes to academic programs. His lab is located at 430E Li Ka Shing Center, and he can be contacted via email at dillin@berkeley.edu or by phone at (510) 664-4951. His work involves exploring fundamental biological processes, and he is actively engaged in advancing scientific understanding within his field.

Research topics

• Biology
• Cell biology
• Computer Science
• Chemistry
• Biochemistry
• Evolutionary biology
• Genetics

Selected publications

• Mitochondria as Cellular and Organismal Signaling Hubs

  Annual Review of Cell and Developmental Biology · 2022 · 180 citations

  Senior authorCorresponding

  Mitochondria are traditionally known as the powerhouse of the cell, but their functions extend far beyond energy production. They are vital in cellular and organismal pathways that direct metabolism, stress responses, immunity, and cellular fate. To accomplish these tasks, mitochondria have established networks of both intra- and extracellular communication. Intracellularly, these communication routes comprise direct contacts between mitochondria and other subcellular components as well as indir…

  DOI

• Four glial cells regulate ER stress resistance and longevity via neuropeptide signaling in <i>C. elegans</i>

  Science · 2020 · 149 citations

  Senior authorCorresponding

  and life-span extension. Thus, astrocyte-like glial cells play a role in regulating organismal ER stress resistance and longevity.

  DOI

• The germline coordinates mitokine signaling

  Cell · 2024-07-02 · 29 citations

  articleOpen accessSenior author
  PublisherOA PDFDOI

• Inter-tissue communication of mitochondrial stress and metabolic health

  Life Metabolism · 2023-01-07 · 28 citations

  articleOpen accessSenior authorCorresponding

  Mitochondria function as a hub of the cellular metabolic network. Mitochondrial stress is closely associated with aging and a variety of diseases, including neurodegeneration and cancer. Cells autonomously elicit specific stress responses to cope with mitochondrial stress to maintain mitochondrial homeostasis. Interestingly, mitochondrial stress responses may also be induced in a non-autonomous manner in cells or tissues that are not directly experiencing such stress. Such non-autonomous mitocho…

  PublisherOA PDFDOI

• Lipid homeostasis is essential for a maximal ER stress response

  eLife · 2023-05-22 · 28 citations

  articleOpen accessSenior author

  Changes in lipid metabolism are associated with aging and age-related diseases, including proteopathies. The endoplasmic reticulum (ER) is uniquely a major hub for protein and lipid synthesis, making its function essential for both protein and lipid homeostasis. However, it is less clear how lipid metabolism and protein quality may impact each other. Here, we identified let-767 , a putative hydroxysteroid dehydrogenase in Caenorhabditis elegans , as an essential gene for both lipid and ER protei…

  PublisherDOI

Recent grants

• NIH Grant R01AG042679

  NIH · $1.5M · 2019

• The Collapse of Proteostasis during Aging is Mediated by Cytoskeletal Actin Functions

  NIH · $1.3M · 2017–2024

• Neuroendocrine Coordination of Mitochondrial Stress Signaling and Proteostasis

  NIH · $4.6M · 2012–2026

Frequent coauthors

• Jenni Durieux

  University of California, Berkeley

  83 shared

• Phillip A. Frankino

  Howard Hughes Medical Institute

  82 shared

• Ryo Higuchi‐Sanabria

  University of Southern California

  75 shared

• Raz Bar‐Ziv

  Howard Hughes Medical Institute

  54 shared

• Holly K. Gildea

  University of California, Berkeley

  47 shared

• Sarah U. Tronnes

  44 shared

• Milos S. Simic

  University of California, San Francisco

  43 shared

• Ashley E. Frakes

  Howard Hughes Medical Institute

  42 shared

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