About

Kyle Mathews is associated with the College of Veterinary Medicine at NC State University, where he is involved in activities related to student engagement and the broader academic community. The page highlights his role as the CVM Director of Student Engagement, indicating his focus on fostering a supportive and collaborative campus environment for veterinary students. His work emphasizes enriching student experiences through extracurricular opportunities, research projects, and international programs, contributing to the development of future veterinary professionals. The information provided does not detail specific research areas, background, or key contributions beyond his leadership in student engagement and community building within the college.

Research topics

• Medicine
• Internal medicine
• Cardiology
• Biology
• Biomedical engineering
• Cell biology
• Surgery
• Radiology
• Chemistry
• Pathology
• Materials science
• Anatomy

Selected publications

• Patch grafting, strategies for transplantation of organoids into solid organs such as liver

  Biomaterials · 2021 · 37 citations

  • Cell biology
  • Biology
  • Pathology
  DOI

• Development of an ultrasound-guided transgluteal injection of the pudendal nerve in cats: a cadaveric study

  Veterinary Anaesthesia and Analgesia · 2021 · 7 citations

  • Medicine
  • Anatomy
  • Surgery
  PublisherDOI

• Cardiac Stromal Cell Patch Integrated with Engineered Microvessels Improves Recovery from Myocardial Infarction in Rats and Pigs

  ACS Biomaterials Science & Engineering · 2020 · 43 citations

  • Biomedical engineering
  • Cardiology
  • Materials science

  The vascularized cardiac patch strategy is promising for ischemic heart repair after myocardial infarction (MI), but current fabrication processes are quite complicated. Vascularized cardiac patches that can promote concurrent restoration of both the myocardium and vasculature at the injured site in a large animal model remain elusive. The safety and therapeutic benefits of a cardiac stromal cell patch integrated with engineered biomimetic microvessels (BMVs) were determined for treating MI. By leveraging a microfluidic method employing hydrodynamic focusing, we constructed the endothelialized microvessels and then encapsulated them together with therapeutic cardiosphere-derived stromal cells (CSCs) in a fibrin gel to generate a prevascularized cardiac stromal cell patch (BMV-CSC patch). We showed that BMV-CSC patch transplantation significantly promoted cardiac function, reduced scar size, increased viable myocardial tissue, promoted neovascularization, and suppressed inflammation in rat and porcine MI models, demonstrating enhanced therapeutic efficacy compared to conventional cardiac stromal cell patches. BMV-CSC patches did not increase renal and hepatic toxicity or exhibit immunogenicity. We noted a significant increase in endogenous progenitor cell recruitment to the peri-infarct region of the porcine hearts treated with BMV-CSC patch as compared to those that received control treatments. These findings establish the BMV-CSC patch as a novel engineered-tissue therapeutic for ischemic tissue repair.

  DOI

• An off-the-shelf artificial cardiac patch improves cardiac repair after myocardial infarction in rats and pigs

  Science Translational Medicine · 2020 · 204 citations

  • Medicine
  • Cardiology
  • Internal medicine

  Cell therapy has been a promising strategy for cardiac repair after injury or infarction; however, low retention and engraftment of transplanted cells limit potential therapeutic efficacy. Seeding scaffold material with cells to create cardiac patches that are transplanted onto the surface of the heart can overcome these limitations. However, because patches need to be freshly prepared to maintain cell viability, long-term storage is not feasible and limits clinical applicability. Here, we developed an off-the-shelf therapeutic cardiac patch composed of a decellularized porcine myocardial extracellular matrix scaffold and synthetic cardiac stromal cells (synCSCs) generated by encapsulating secreted factors from isolated human cardiac stromal cells. This fully acellular artificial cardiac patch (artCP) maintained its potency after long-term cryopreservation. In a rat model of acute myocardial infarction, transplantation of the artCP supported cardiac recovery by reducing scarring, promoting angiomyogenesis, and boosting cardiac function. The safety and efficacy of the artCP were further confirmed in a porcine model of myocardial infarction. The artCP is a clinically feasible, easy-to-store, and cell-free alternative to myocardial repair using cell-based cardiac patches.

  DOI

Frequent coauthors

• Simon C. Roe

  North Carolina State University

  26 shared

• B. Duncan X. Lascelles

  North Carolina State University

  15 shared

• Clare R. Gregory

  14 shared

• Gary W. Ellison

  University of Florida

  12 shared

• Peter L. Mente

  University of North Carolina at Chapel Hill

  11 shared

• Scott T. Murphy

  University of Florida

  11 shared

• Lillian R. Aronson

  Hospital of the University of Pennsylvania

  10 shared

• Kent J. Vince

  Wright-Patterson Air Force Base

  9 shared

Labs

• CVM: Research Area of Emphasis: Spontaneous Animal Disease Models, Veterinary Cancer CarePI

Awards & honors

• Diplomate, American College of Veterinary Surgeons

Similar researchers at North Carolina State University

• Jonathan Lindseyh-101
• Edward Breitschwerdth-100
• José Alonsoh-94
• Rob Dunnh-94
• Frances S. Liglerh-92