Jonathan Lindsey

About

Jonathan Lindsey is a professor and the Glaxo Distinguished University Chair at NC State University, based in the Department of Chemistry. He holds a B.S. in Chemistry with Distinction and Honors from Indiana University, obtained in 1978, and a Ph.D. in Chemistry from The Rockefeller University, completed in 1983. Following his doctoral studies, he was a Postdoctoral Fellow at The Rockefeller University in 1984. His research focuses on organic chemistry for cancer diagnosis and novel therapeutics, studies of organic natural product biodiversity in cyanobacteria, and synthetic tetrapyrrole chemistry including chlorophylls. His work is associated with the fields of chemical biology, drug discovery, energy, and organic chemistry, contributing to the understanding and development of organic compounds with biomedical applications.

Research topics

• Physics
• Chemistry
• Optics
• Organic chemistry
• Photochemistry
• Computer Science
• Chromatography
• Atomic physics
• Computational biology
• Biology

Selected publications

• Comprehensive review of photophysical parameters (ε, Φf, τs) of tetraphenylporphyrin (H2TPP) and zinc tetraphenylporphyrin (ZnTPP) – Critical benchmark molecules in photochemistry and photosynthesis

  Journal of Photochemistry and Photobiology C Photochemistry Reviews · 2021 · 191 citations

  DOI

• Absorption and Fluorescence Spectral Database of Chlorophylls and Analogues

  Photochemistry and Photobiology · 2020 · 137 citations

  Senior authorCorresponding

  , protochlorophyll a), chlorin (e.g. chlorophyll a, bacteriochlorophyll c) or bacteriochlorin (e.g. bacteriochlorophyll a). Altogether, the database contains 305 absorption spectra (from 19 porphyrins, 109 chlorins and 22 bacteriochlorins) and 72 fluorescence spectra (from 10 porphyrins, 30 chlorins and 4 bacteriochlorins). The spectral database should facilitate comparisons and quantitative calculations. All spectra are available in print form in the Supporting Information. The entire database…

  DOI

• Digital Database of Absorption Spectra of Diverse Flavonoids Enables Structural Comparisons and Quantitative Evaluations

  Journal of Natural Products · 2023 · 103 citations

  Senior authorCorresponding

  .

  DOI

• Synthesis of compact water-soluble bioconjugatable porphyrins for life sciences applications

  New Journal of Chemistry · 2025-01-01 · 6 citations

  articleOpen accessSenior authorCorresponding

  Porphyrins substituted in a trans -AB pattern bearing a single bioconjugatable group (A) and a single water-solubilizing motif (B) with limited molecular weight were synthesized for potential use in aqueous solution.

  PublisherOA PDFDOI

• Performance of chatbots in queries concerning fundamental concepts in photochemistry

  Photochemistry and Photobiology · 2024-11-04 · 6 citations

  articleOpen accessSenior authorCorresponding

  The advent of chatbots raises the possibility of a paradigm shift across society including the most technical of fields with regard to access to information, generation of knowledge, and dissemination of education and training. Photochemistry is a scientific endeavor with roots in chemistry and physics and branches that encompass diverse disciplines ranging from astronomy to zoology. Here, five chatbots have each been challenged with 13 photochemically relevant queries. The chatbots included Cha…

  PublisherOA PDFDOI

Recent grants

• NIH Grant R01GM036238

  NIH · $4.4M · 2007

• Versatile Synthesis of Chlorophylls and Bacteriochlorophylls for Fundamental Studies in Photosynthesis

  NSF · $450k · 2018–2021

• A Chemical Model for the Prebiotic Origins of Tetrapyrrole Macrocycles

  NSF · $510k · 2010–2013

Frequent coauthors

• David F. Bocian

  University of California, Riverside

  530 shared

• Dewey Holten

  Washington University in St. Louis

  320 shared

• Masahiko Taniguchi

  Osaka University of Pharmaceutical Sciences

  204 shared

• James R. Diers

  University of California, Riverside

  190 shared

• Christine Kirmaier

  Washington University in St. Louis

  163 shared

• Robert S. Loewe

  North Carolina State University

  78 shared

• Richard W. Wagner

  The University of Texas MD Anderson Cancer Center

  69 shared

• Eve Hindin

  North Carolina State University

  63 shared

Labs

• Jonathan LindseyPI

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• Yi Xiaoh-68