Yuan Wu
· Associate Professor in Biostatistics & BioinformaticsDuke University · Environmental Science & Policy
Active 2007–2025
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About
Yuan Wu is an Associate Professor in Biostatistics & Bioinformatics at Duke University and a member of the Duke Cancer Institute. He is based at the Duke Department of Biostatistics and Bioinformatics, located at 2424 Erwin Road, Durham, NC. His professional role involves research and teaching within the division of Biostatistics, contributing to the academic and clinical research community at Duke.
Research topics
- Physics
- Optics
- Nuclear physics
- Materials science
- Atomic physics
Selected publications
Journal for ImmunoTherapy of Cancer · 2021-03-01 · 113 citations
articleOpen accessBackground Low-density lipoprotein receptor-related protein 1b (encoded by LRP1B ) is a putative tumor suppressor, and preliminary evidence suggests LRP1B- mutated cancers may have improved outcomes with immune checkpoint inhibitors (ICI). Methods We conducted a multicenter, retrospective pan-cancer analysis of patients with LRP1B alterations treated with ICI at Duke University, Johns Hopkins University (JHU) and University of Michigan (UM). The primary objective was to assess the association be…
Biosensors and Bioelectronics · 2021-03-29 · 99 citations
articleJCI Insight · 2025-01-07 · 4 citations
articleOpen accessSince multiple front-line immune checkpoint inhibitor-based (ICI-based) combinations are approved for metastatic renal cell carcinoma, biomarkers predicting for ICI responses are needed past clinical prognostication scores and transcriptome gene expression profiling. Circulating markers represent opportunities to assess baseline and dynamic changes in immune cell frequency and cytokine levels while on treatment. We conducted an exploratory prospective correlative study of 33 patients with metast…
npj Precision Oncology · 2025-01-29 · 2 citations
articleOpen accessBlack men suffer disproportionately from prostate cancer (PCa) compared to men of other races and ethnicities. Comparing the molecular landscape of PCa among Black and White patients has the potential to identify targets for development of new precision medicine interventions. Herein, we conducted transcriptomic analysis of prostate tumors and paired tumor-adjacent normals from self-reported Black and White PCa patients and estimated patient genetic ancestry. Clinical follow-up revealed increase…
Group Sequential Test for Two‐Sample Ordinal Outcome Measures
Statistics in Medicine · 2025-03-15 · 1 citations
articleOpen access1st authorCorrespondingGroup sequential trials include interim monitoring points to potentially reach futility or efficacy decisions early. This approach to trial design can safeguard patients, provide efficacious treatments for patients early, and save money and time. Group sequential methods are well developed for bell-shaped continuous, binary, and time-to-event outcomes. In this paper, we propose a group sequential design using the Mann-Whitney-Wilcoxon test for general two-sample ordinal data. We establish that t…
Frequent coauthors
- 157 shared
M. W. Ahmed
University of Missouri–Kansas City
- 123 shared
V. Popov
Duke University
- 116 shared
S.F. Mikhailov
Duke University
- 70 shared
B. A. Perdue
- 65 shared
H. R. Weller
Duke University
- 60 shared
R. E. Pywell
University of Saskatchewan
- 57 shared
V.N. Litvinenko
- 57 shared
B. Norum
Duke University
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