Elizabeth Louise Turner
· Associate Professor of Biostatistics & BioinformaticsDuke University · Environmental Science & Policy
Active 1914–2026
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About
Professor Elizabeth Louise Turner is associated with the Duke Center for Combinatorial Gene Regulation, which is an NIH Center of Excellence in Genomic Science. The center aims to make combinatorial studies of the function of regulatory elements and noncoding variants routine. Its goal is to develop a systematic and comprehensive framework for determining the effects of combinations of regulatory elements on gene expression and downstream phenotypes. This work is expected to transform human disease studies by prioritizing genes for targeted study and drug design, and by predicting the pathogenicity of noncoding variants that have not been observed, which is crucial for whole genome sequencing studies of both rare and common diseases.
Research topics
- Medicine
- Psychiatry
- Computer Science
- Internal medicine
- Psychology
- Nursing
- Political Science
- Family medicine
- Computer network
- Pediatrics
Selected publications
A Community-Based Intervention for Managing Hypertension in Rural South Asia
New England Journal of Medicine · 2020 · 299 citations
BACKGROUND: The burden of hypertension is escalating, and control rates are poor in low- and middle-income countries. Cardiovascular mortality is high in rural areas. METHODS: We conducted a cluster-randomized, controlled trial in rural districts in Bangladesh, Pakistan, and Sri Lanka. A total of 30 communities were randomly assigned to either a multicomponent intervention (intervention group) or usual care (control group). The intervention involved home visits by trained government community he…
Social Science & Medicine · 2020 · 174 citations
The Lancet Global Health · 2020 · 142 citations
BACKGROUND: The burden of malaria infection in sub-Saharan Africa among school-aged children aged 5-15 years is underappreciated and represents an important source of human-to-mosquito transmission of Plasmodium falciparum. Additional interventions are needed to control and eliminate malaria. We aimed to assess whether preventive treatment of malaria might be an effective means of reducing P falciparum infection and anaemia in school-aged children and lowering parasite transmission. METHODS: In…
BMC Psychiatry · 2020 · 74 citations
BACKGROUND: The mental health treatment gap-the difference between those with mental health need and those who receive treatment-is high in low- and middle-income countries. Task-shifting has been used to address the shortage of mental health professionals, with a growing body of research demonstrating the effectiveness of mental health interventions delivered through task-shifting. However, very little research has focused on how to embed, support, and sustain task-shifting in government-funded…
JAMA · 2023 · 67 citations
IMPORTANCE: Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective: To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS: In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non-critically ill hospitalized adults were randomized to rece…
Frequent coauthors
- 127 shared
John A. Gallis
Duke University
- 68 shared
Wendy Prudhomme O’Meara
Duke University
- 64 shared
Fan Li
Yale University
- 53 shared
Karen O’Donnell
- 47 shared
Siham Sikander
University of Liverpool
- 46 shared
Dorothy E. Dow
- 39 shared
Ryan Simmons
Center for Autism and Related Disorders
- 37 shared
Lijing L. Yan
Duke Kunshan University
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