About

Ying S. Wang, DDS, MS, is a Clinical Assistant Professor at Texas A&M University College of Dentistry in the Department of Periodontics, where she also serves as the Assistant Program Director of the Postdoctoral Periodontics Program. She is a Diplomate of the American Board of Periodontology. Dr. Wang received her dental degree from Kyushu University in Fukuoka, Japan, in 2014. After completing her training in oral and maxillofacial surgery and a hospital internship, she spent three years practicing in private general practice in Hiroshima, Japan. She further pursued her education at The Ohio State University, earning her Certificate in Periodontics and her Master of Science degree in 2021, during which she served as the Chief Periodontal Resident. Her research interests focus on soft tissue surgical procedures and dental implants, and she has been involved in clinical trials and systematic reviews.

Research topics

• Medicine
• Computer Science
• Pathology
• Surgery
• Internal medicine
• Art
• Dentistry
• Mechanical engineering
• Biology
• Statistics
• Physics
• Mathematics
• Engineering

Selected publications

• Apoptotic cell death in disease—Current understanding of the NCCD 2023

  Cell Death and Differentiation · 2023 · 344 citations

  • Biology
  • Cell biology
  • Immunology
  PublisherOA PDFDOI

• Intra-marrow penetrations and root coverage outcomes: a systematic review

  BMC Oral Health · 2023 · 2 citations

  • Medicine
  • Surgery
  • Pathology

  BACKGROUND: Intra-marrow penetrations (IMPs) have been performed during guided tissue regeneration (GTR) procedures with reported clinical benefits. The aim of this systematic review was to investigate the use and effect of IMPs during root coverage procedures. METHOD: A broad search for human and animal studies was performed on PubMed, Cochrane Database of Systematic Reviews and Cochrane Central Registry of Controlled Trials and Web of Science, following a registered review protocol (PROSPERO). All prospective study designs, case series and case reports on gingival recession treatment (follow-up ≥ 6 months) that employed IMPs were included. Root coverage, complete root coverage prevalence, and adverse effects were recorded, and risk of bias was assessed. RESULTS: Of 16,181 screened titles, 5 articles (all of them human studies) met inclusion criteria. All studies (including two randomized clinical trials) treated Miller class I and II recession defects, using coronally advanced flap with IMPs alone or in conjunction with GTR protocols. Therefore, all treated defects received IMPs and no studies compared protocols with and without IMPs. Outcomes were indirectly compared with existing root coverage literature. Mean root coverage was 2.7 mm and 68.5% at 6.8 months (median: 6 months, range 6-15 months) for sites treated with IMPs. CONCLUSION: IMPs are rarely used during root coverage procedures, have not been associated with intra-surgical or wound healing adverse effects and have not been investigated as independent factor. Future clinical studies are needed to directly compare treatment protocols with and without IMPs and investigate the potential benefits of IMPs for root coverage.

  DOI

• Accuracy of mechanical torque-limiting devices for implant screw tightening: A systematic review and meta-analysis

  Journal of Prosthetic Dentistry · 2022 · 9 citations

  1st authorCorresponding
  • Computer Science
  • Statistics
  • Computer Science
  DOI

• Targeting Hypoxic Tumors with Hybrid Nanobullets for Oxygen-Independent Synergistic Photothermal and Thermodynamic Therapy

  Nano-Micro Letters · 2021 · 116 citations

  • Chemistry
  • Cancer research
  • Biochemistry

  Hypoxia is a feature of solid tumors and it hinders the therapeutic efficacy of oxygen-dependent cancer treatment. Herein, we have developed all-organic oxygen-independent hybrid nanobullets ZPA@HA-ACVA-AZ for the "precise strike" of hypoxic tumors through the dual-targeting effects from surface-modified hyaluronic acid (HA) and hypoxia-dependent factor carbonic anhydrase IX (CA IX)-inhibitor acetazolamide (AZ). The core of nanobullets is the special zinc (II) phthalocyanine aggregates (ZPA) which could heat the tumor tissues upon 808-nm laser irradiation for photothermal therapy (PTT), along with the alkyl chain-functionalized thermally decomposable radical initiator ACVA-HDA on the side chain of HA for providing oxygen-independent alkyl radicals for ablating hypoxic cancer cells by thermodynamic therapy (TDT). The results provide important evidence that the combination of reverse hypoxia hallmarks CA IX as targets for inhibition by AZ and synergistic PTT/TDT possess incomparable therapeutic advantages over traditional (reactive oxygen species (ROS)-mediated) cancer treatment for suppressing the growth of both hypoxic tumors and their metastasis.

  DOI

• Oscillating features in the electromagnetic structure of the neutron

  Nature Physics · 2021 · 87 citations

  • Physics
  • Nuclear physics
  DOI

• Multiple Epithelial Origin Complications Following Subepithelial Connective Tissue Graft for Root Coverage

  Clinical Advances in Periodontics · 2021 · 8 citations

  1st authorCorresponding
  • Medicine
  • Surgery
  • Dentistry

  INTRODUCTION: The subepithelial connective tissue graft (SCTG) and flap combination is a highly predictable root coverage procedure, with low complication rates. To our knowledge, this article reports the first case of two late SCTG complications, epithelial cell discharge, and subsequent epidermal inclusion cyst (EIC) formation. CASE PRESENTATION: A 35-year-old male presented with a 3-mm deep Miller Class II recession defect on the mandibular right canine and mesial root of mandibular right first molar. A mild discomfort was reported at 8 weeks after envelope flap+SCTG in #27. At 4 months after the procedure, the patient presented with persistent discomfort and minimally compressible recipient site diffuse swelling with discharge, which was cytologically diagnosed as normal epithelial cells. One year postoperatively, enlargement of the lesion was seen, and excisional biopsy was performed simultaneously with SCTG in #30. The lesion was diagnosed as EIC. At 8 months follow-up, the site healed uneventfully, the patient remained asymptomatic, and the site exhibited scar formation and no recurrence of the lesion. CONCLUSION: This report highlights epithelial cell discharge and EIC formation as a rare yet possible SCTG complication and emphasizes the importance of an excisional biopsy as the means to obtain a definitive diagnosis and manage this complication.

  DOI

• Proteogenomic Characterization of Endometrial Carcinoma

  Cell · 2020 · 526 citations

  • Biology
  • Computational biology
  • Cancer research

  We undertook a comprehensive proteogenomic characterization of 95 prospectively collected endometrial carcinomas, comprising 83 endometrioid and 12 serous tumors. This analysis revealed possible new consequences of perturbations to the p53 and Wnt/β-catenin pathways, identified a potential role for circRNAs in the epithelial-mesenchymal transition, and provided new information about proteomic markers of clinical and genomic tumor subgroups, including relationships to known druggable pathways. An extensive genome-wide acetylation survey yielded insights into regulatory mechanisms linking Wnt signaling and histone acetylation. We also characterized aspects of the tumor immune landscape, including immunogenic alterations, neoantigens, common cancer/testis antigens, and the immune microenvironment, all of which can inform immunotherapy decisions. Collectively, our multi-omic analyses provide a valuable resource for researchers and clinicians, identify new molecular associations of potential mechanistic significance in the development of endometrial cancers, and suggest novel approaches for identifying potential therapeutic targets.

  DOI

Frequent coauthors

• Dimitris N. Tatakis

  The Ohio State University

  3 shared

• Vrisiis Kofina

  Marquette University

  2 shared

• Alissa Fial

  Marquette University

  2 shared

• Kristin K. McNamara

  1 shared

• Kalia Theodorou

  The Ohio State University

  1 shared

• C. Brett

  University of Tennessee at Knoxville

  1 shared

• Eswar Kandaswamy

  Louisiana State University Health Sciences Center New Orleans

  1 shared

• Caroline Bissonnette

  1 shared

Education

• MS, Division of Periodontology

  College of Dentistry, Ohio State University

• DDS

  Kyushu University

Awards & honors

• Diplomate of the American Board of Periodontology

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