Stephen Safe

About

Stephen Safe is a professor associated with the Texas A&M University College of Veterinary Medicine & Biomedical Sciences (VMBS). The college is recognized as a leading institution in veterinary education and research, supporting collaborations that translate discoveries into solutions for animal, human, and environmental health. The college emphasizes innovative research, including basic and clinical studies, with a focus on a 'One Health' approach that recognizes the complex interactions between animal, human, and environmental health. While the specific research focus and key contributions of Stephen Safe are not detailed in the provided page text, his association with VMBS suggests involvement in a dynamic environment dedicated to advancing veterinary medicine through cutting-edge research, education, and outreach efforts.

Research topics

• Biology
• Biochemistry
• Pharmacology
• Chemistry
• Cancer research
• Computer Science
• Medicine
• Cell biology
• Immunology
• Internal medicine

Selected publications

• Flavonoids: structure–function and mechanisms of action and opportunities for drug development

  Toxicological Research · 2021 · 162 citations

  1st authorCorresponding
  DOI

• The Paradoxical Roles of Orphan Nuclear Receptor 4A (NR4A) in Cancer

  Molecular Cancer Research · 2020 · 142 citations

  1st authorCorresponding

  double knockout mice rapidly develop acute myelocytic leukemia, suggesting that these receptors exhibit tumor suppressor activity. Treatment of leukemia and most lymphoma cells with drugs that induce expression of NR4A1and NR4A3 enhances apoptosis, and this represents a potential clinical application for treating this disease. In contrast, most solid tumor-derived cell lines express high levels of NR4A1 and NR4A2, and both receptors exhibit pro-oncogenic activities in solid tumors, whereas NR4A3…

  DOI

• Aryl Hydrocarbon Receptor (AHR) Ligands as Selective AHR Modulators (SAhRMs)

  International Journal of Molecular Sciences · 2020 · 127 citations

  1st authorCorresponding

  The aryl hydrocarbon receptor (AhR) was first identified as the intracellular protein that bound and mediated the toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) and dioxin-like compounds (DLCs). Subsequent studies show that the AhR plays an important role in maintaining cellular homeostasis and in pathophysiology, and there is increasing evidence that the AhR is an important drug target. The AhR binds structurally diverse compounds, including pharmaceuticals, phytochemicals…

  DOI

• The 2022 world health organization reevaluation of human and mammalian toxic equivalency factors for polychlorinated dioxins, dibenzofurans and biphenyls

  Regulatory Toxicology and Pharmacology · 2023 · 98 citations

  PublisherOA PDFDOI

• CXCL11-CXCR3 Axis Mediates Tumor Lymphatic Cross Talk and Inflammation-Induced Tumor, Promoting Pathways in Head and Neck Cancers

  American Journal Of Pathology · 2020 · 51 citations

  DODA-Me in abrogating several of these tumor-promoting pathways.

  DOI

Recent grants

• NIH Grant R01CA104116

  NIH · $682k · 2009

• NIH Grant R01CA076636

  NIH · $543k · 2003

• NIH Grant R01CA142697

  NIH · $1.3M · 2017

Frequent coauthors

• Maen Abdelrahim

  Houston Methodist

  252 shared

• Syng‐Ook Lee

  232 shared

• Sudhakar Chintharlapalli

  221 shared

• Kumaravel Mohankumar

  131 shared

• Kyounghyun Kim

  University of Arkansas for Medical Sciences

  129 shared

• Kyungsil Yoon

  127 shared

• Sabitha Papineni

  122 shared

• Erik Hedrick

  97 shared

Similar researchers at Texas A&M University

• Larry J Suvah-68
• Timothy Phillipsh-58
• Weihsueh Chiuh-53