Yihui Zhou

About

Yi-Hui Zhou, PhD, is a researcher leading the High Dimensional Predictive Biology Lab. The lab's focus includes human microbiome analysis, methods development, and the application of machine learning techniques to discover disease genetics and perform prediction. Their work also encompasses computational toxicology, integrative analysis of 'omics data, high dimensional statistics and inference, biomedical data analysis, and single-cell RNA-sequencing analysis. Dr. Zhou's research aims to advance understanding and methodologies in these areas to contribute to biomedical and health-related discoveries.

Research topics

• Medicine
• Biology
• Computer Science
• Geography
• Biochemistry
• Chemistry
• Internal medicine
• Engineering
• Library science
• Genetics

Selected publications

• The COVID-19 Pandemic Vulnerability Index (PVI) Dashboard: Monitoring County-Level Vulnerability Using Visualization, Statistical Modeling, and Machine Learning

  Environmental Health Perspectives · 2021 · 93 citations

  DOI

• Risk Characterization of Environmental Samples Using<i>In Vitro</i>Bioactivity and Polycyclic Aromatic Hydrocarbon Concentrations Data

  Toxicological Sciences · 2020 · 51 citations

  Methods to assess environmental exposure to hazardous chemicals have primarily focused on quantification of individual chemicals, although chemicals often occur in mixtures, presenting challenges to the traditional risk characterization framework. Sampling sites in a defined geographic region provide an opportunity to characterize chemical contaminants, with spatial interpolation as a tool to provide estimates for non-sampled sites. At the same time, the use of in vitro bioactivity measurements…

  DOI

• Complete CFTR gene sequencing in 5,058 individuals with cystic fibrosis informs variant-specific treatment

  Journal of Cystic Fibrosis · 2021 · 38 citations

  DOI

• Hazard and risk characterization of 56 structurally diverse PFAS using a targeted battery of broad coverage assays using six human cell types

  Toxicology · 2024-02-27 · 37 citations

  articleOpen access
  PublisherOA PDFDOI

• Liver eQTL meta-analysis illuminates potential molecular mechanisms of cardiometabolic traits

  The American Journal of Human Genetics · 2024-08-22 · 20 citations

  reviewOpen access
  PublisherOA PDFDOI

Recent grants

• Permutation Approximations for Next Generation Association

  NIH · $417k · 2015–2018

Frequent coauthors

• Fred A. Wright

  64 shared

• Michael J. Bamshad

  Brotman Baty Institute

  35 shared

• Michael R. Knowles

  Lung Institute

  31 shared

• Scott M. Blackman

  Johns Hopkins University

  30 shared

• Garry R. Cutting

  Johns Hopkins Medicine

  28 shared

• Rhonda G. Pace

  Lung Institute

  27 shared

• Paul J. Gallins

  North Carolina State University

  23 shared

• Ronald L. Gibson

  Seattle Children's Hospital

  19 shared

Education

• PhD, Biostatitsics

  University of North Carolina at Chapel Hill

  2011

Similar researchers at North Carolina State University

• José Alonsoh-94
• Anastasios A Tsiatish-80
• David C Muddimanh-71