David C Muddiman
· ProfessorNorth Carolina State University · Plant and Microbial Biology
Active 1994–2026
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About
David C Muddiman is the Jacob and Betty Belin Distinguished Professor of Chemistry and serves as the Associate Head for Research at NC State University. His research group focuses on developing innovative mass spectrometry measurements to address important biological problems. His projects include the development of an ambient ionization method called IR-MALDESI, which is applied to a diverse range of materials such as soft tissue, plants, textiles, and bone. Additionally, his group works on advanced separation techniques to enable detailed characterization of complex biological samples. Dr. Muddiman's expertise lies in analytical chemical biology, with a particular emphasis on applying mass spectrometry to solve biological questions.
Research topics
- Chemistry
- Internal medicine
- Biochemistry
- Biology
- Medicine
- Optics
- Physics
- Endocrinology
- Chromatography
- Genetics
Selected publications
Mass Spectrometry Reviews · 2021 · 80 citations
Senior authorCorrespondingIn the past 15 years, ambient ionization techniques have witnessed a significant incursion into the field of mass spectrometry imaging, demonstrating their ability to provide complementary information to matrix-assisted laser desorption ionization. Matrix-assisted laser desorption electrospray ionization is one such technique that has evolved since its first demonstrations with ultraviolet lasers coupled to Fourier transform-ion cyclotron resonance mass spectrometers to extensive use with infrar…
Toxicological Sciences · 2020 · 67 citations
There is a growing need to understand the potential neurotoxicity of organophosphate flame retardants (OPFRs) and plasticizers because use and, consequently, human exposure, is rapidly expanding. We have previously shown in rats that developmental exposure to the commercial flame retardant mixture Firemaster 550 (FM 550), which contains OPFRs, results in sex-specific behavioral effects, and identified the placenta as a potential target of toxicity. The placenta is a critical coordinator of fetal…
Proceedings of the National Academy of Sciences · 2022 · 46 citations
underlies a large metabolic QTL that modulates phosphatidylcholine levels and has an adaptive effect at least in part via induction of early flowering time.
Analytical and Bioanalytical Chemistry · 2025-04-24 · 6 citations
articleOpen accessSenior authorUnderstanding the spatial-temporal molecular dynamics of wound healing is crucial for devising effective treatments. Three-dimensional mass spectrometry imaging (3D MSI) enables the comprehensive visualization of molecular distribution throughout skin layers, offering valuable insights into the wound healing process. However, traditional 3D MSI often faces challenges in maintaining data integrity and accurate image registration in the third dimension. To address this, we employed infrared matrix…
Free Radical Biology and Medicine · 2022 · 6 citations
Recent grants
NIH · $1.1M · 2015
NIH · $347k · 2011
NIH · $403k · 2023
Frequent coauthors
- 87 shared
Peter J. Stang
University of Utah
- 80 shared
Adam M. Hawkridge
Virginia Commonwealth University
- 65 shared
Richard Smith
Pacific Northwest National Laboratory
- 49 shared
Hai‐Bo Yang
East China Normal University
- 27 shared
Angelito I. Nepomuceno
North Carolina State University
- 26 shared
H. Robert Bergen
- 25 shared
Kenneth P. Garrard
North Carolina State University
- 24 shared
Quanzi Li
Chinese Academy of Forestry
Labs
The Muddiman GroupPI
Awards & honors
- AAAS Fellow
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