Y.A. Liu
· Professor of Chemical EngineeringVerifiedVirginia Tech · Chemical Engineering
Active 1991–2023
About
Y.A. Liu is an endowed professor and a distinguished faculty member in the Department of Chemical Engineering at Virginia Tech. He holds a Ph.D. from Princeton University obtained in 1974, a Master of Science from Tufts University earned in 1970, and a Bachelor of Science from National Taiwan University completed in 1967. His research interests encompass sustainable engineering, process modeling, big data analytics, and energy and water savings. His work focuses on advancing sustainable practices within chemical engineering through innovative process modeling and data-driven approaches. Based in Blacksburg, Virginia, he is actively involved in research and education aimed at developing sustainable solutions for engineering challenges.
Research topics
- Computer Science
- Artificial Intelligence
- Astronomy
- Telecommunications
- Physics
- Mathematics
- Economics
Selected publications
2022 IEEE International Conference on Industrial Technology (ICIT) · 2024
- Computer Science
- Computer Science
- Database
Increasing the linear modulation range
The Lancet · 2024 · 1863 citations
- Medicine
- Demography
- Pediatrics
BACKGROUND: Underweight and obesity are associated with adverse health outcomes throughout the life course. We estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from 1990 to 2022 for adults and school-aged children and adolescents in 200 countries and territories. METHODS: ). For school-aged children and adolescents, we report thinness (BMI <2 SD below the median of the WHO growth reference) and obesity (BMI >2 SD above the median). FINDINGS: From 1990 to 2022, the combined prevalence of underweight and obesity in adults decreased in 11 countries (6%) for women and 17 (9%) for men with a posterior probability of at least 0·80 that the observed changes were true decreases. The combined prevalence increased in 162 countries (81%) for women and 140 countries (70%) for men with a posterior probability of at least 0·80. In 2022, the combined prevalence of underweight and obesity was highest in island nations in the Caribbean and Polynesia and Micronesia, and countries in the Middle East and north Africa. Obesity prevalence was higher than underweight with posterior probability of at least 0·80 in 177 countries (89%) for women and 145 (73%) for men in 2022, whereas the converse was true in 16 countries (8%) for women, and 39 (20%) for men. From 1990 to 2022, the combined prevalence of thinness and obesity decreased among girls in five countries (3%) and among boys in 15 countries (8%) with a posterior probability of at least 0·80, and increased among girls in 140 countries (70%) and boys in 137 countries (69%) with a posterior probability of at least 0·80. The countries with highest combined prevalence of thinness and obesity in school-aged children and adolescents in 2022 were in Polynesia and Micronesia and the Caribbean for both sexes, and Chile and Qatar for boys. Combined prevalence was also high in some countries in south Asia, such as India and Pakistan, where thinness remained prevalent despite having declined. In 2022, obesity in school-aged children and adolescents was more prevalent than thinness with a posterior probability of at least 0·80 among girls in 133 countries (67%) and boys in 125 countries (63%), whereas the converse was true in 35 countries (18%) and 42 countries (21%), respectively. In almost all countries for both adults and school-aged children and adolescents, the increases in double burden were driven by increases in obesity, and decreases in double burden by declining underweight or thinness. INTERPRETATION: The combined burden of underweight and obesity has increased in most countries, driven by an increase in obesity, while underweight and thinness remain prevalent in south Asia and parts of Africa. A healthy nutrition transition that enhances access to nutritious foods is needed to address the remaining burden of underweight while curbing and reversing the increase in obesity. FUNDING: UK Medical Research Council, UK Research and Innovation (Research England), UK Research and Innovation (Innovate UK), and European Union.
arXiv (Cornell University) · 2024
- Physics
- Particle physics
- Nuclear physics
Higgsinos with masses near the electroweak scale can solve the hierarchy problem and provide a dark matter candidate, while detecting them at the LHC remains challenging if their mass splitting is $\mathcal{O}(1 \text{GeV})$. This Letter presents a novel search for nearly mass-degenerate Higgsinos in events with an energetic jet, missing transverse momentum, and a low-momentum track with a significant transverse impact parameter using 140 fb$^{-1}$ of proton-proton collision data at $\sqrt{s}=13$ TeV collected by the ATLAS experiment. For the first time since LEP, a range of mass splittings between the lightest charged and neutral Higgsinos from $0.3$ GeV to $0.9$ GeV is excluded at 95$\%$ confidence level, with a maximum reach of approximately $170$ GeV in the Higgsino mass.
Genetic drivers of heterogeneity in type 2 diabetes pathophysiology
Nature · 2024 · 480 citations
- Biology
- Genetics
- Evolutionary biology
in a further 279,552 individuals of diverse ancestry, including 30,288 cases of T2D, and test their association with T2D-related vascular outcomes. Cluster-specific partitioned polygenic scores are associated with coronary artery disease, peripheral artery disease and end-stage diabetic nephropathy across ancestry groups, highlighting the importance of obesity-related processes in the development of vascular outcomes. Our findings show the value of integrating multi-ancestry genome-wide association study data with single-cell epigenomics to disentangle the aetiological heterogeneity that drives the development and progression of T2D. This might offer a route to optimize global access to genetically informed diabetes care.
Annals of Internal Medicine · 2023 · 85 citations
- Medicine
- Internal medicine
- Endocrinology
BACKGROUND: In patients with chronic kidney disease (CKD) and type 2 diabetes (T2D), finerenone, a nonsteroidal mineralocorticoid receptor antagonist, reduces cardiovascular and kidney failure outcomes. Finerenone also lowers the urine albumin-to-creatinine ratio (UACR). Whether finerenone-induced change in UACR mediates cardiovascular and kidney failure outcomes is unknown. OBJECTIVE: To quantify the proportion of kidney and cardiovascular risk reductions seen over a 4-year period mediated by a change in kidney injury, as measured by the change in log UACR between baseline and month 4. DESIGN: Post hoc mediation analysis using pooled data from 2 phase 3, double-blind trials of finerenone. (ClinicalTrials.gov: NCT02540993 and NCT02545049). SETTING: Several clinical sites in 48 countries. PATIENTS: 12 512 patients with CKD and T2D. INTERVENTION: Finerenone and placebo (1:1). MEASUREMENTS: Separate mediation analyses were done for the composite kidney (kidney failure, sustained ≥57% decrease in estimated glomerular filtration rate from baseline [approximately a doubling of serum creatinine], or kidney disease death) and cardiovascular (cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure) outcomes. RESULTS: At baseline, median UACR was 514 mg/g. A 30% or greater reduction in UACR was seen in 3338 (53.2%) patients in the finerenone group and 1684 (27.0%) patients in the placebo group. Reduction in UACR (analyzed as a continuous variable) mediated 84% and 37% of the treatment effect on the kidney and cardiovascular outcomes, respectively. When change in UACR was analyzed as a binary variable (that is, whether the guideline-recommended 30% reduction threshold was met), the proportions mediated for each outcome were 64% and 26%, respectively. LIMITATION: The current findings are not readily extendable to other drugs. CONCLUSION: In patients with CKD and T2D, early albuminuria reduction accounted for a large proportion of the treatment effect against CKD progression and a modest proportion of the effect against cardiovascular outcomes. PRIMARY FUNDING SOURCE: Bayer AG.
Computer-Aided Design and Applications · 2023 · 1 citations
- Computer Science
- Artificial Intelligence
- Mathematics
Computer-Aided Design and Applications is an international journal on the applications of CAD and CAM. It publishes papers in the general domain of CAD plus in emerging fields like bio-CAD, nano-CAD, soft-CAD, garment-CAD, PLM, PDM, CAD data mining, CAD and the internet, CAD education, genetic algorithms and CAD engines. The journal is aimed at all developers and users of CAD technology to ptovide CAD solutions for various stages of design and manufacturing. The journal publishes all about Computer-Aided Design and Computer-Aided technologies.
arXiv (Cornell University) · 2023 · 2 citations
- Physics
- Particle physics
- Nuclear physics
Measurements of both the inclusive and differential production cross sections of a top-quark-top-antiquark pair in association with a $Z$ boson ($t\bar{t}Z$) are presented. Final states with two, three or four isolated leptons (electrons or muons) are targeted. The measurements use the data recorded by the ATLAS detector in $pp$ collisions at $\sqrt{s}=13$ TeV at the Large Hadron Collider during the years 2015-2018, corresponding to an integrated luminosity of $140$ fb$^{-1}$. The inclusive cross section is measured to be $\sigma_{t\bar{t}Z}= 0.86 \pm 0.04~\mathrm{(stat.)} \pm 0.04~\mathrm{(syst.)}~$pb and found to be in agreement with the most advanced Standard Model predictions. The differential measurements are presented as a function of a number of observables that probe the kinematics of the $t\bar{t}Z$ system. Both the absolute and normalised differential cross-section measurements are performed at particle level and parton level for specific fiducial volumes, and are compared with NLO+NNLL theoretical predictions. The results are interpreted in the framework of Standard Model effective field theory and used to set limits on a large number of dimension-6 operators involving the top quark. The first measurement of spin correlations in $t\bar{t}Z$ events is presented: the results are in agreement with the Standard Model expectations, and the null hypothesis of no spin correlations is disfavoured with a significance of $1.8$ standard deviations.
arXiv (Cornell University) · 2023 · 1 citations
- Physics
- Particle physics
- Nuclear physics
Measurements of the substructure of top-quark jets are presented, using 140 fb$^{-1}$ of 13 TeV $pp$ collision data recorded with the ATLAS detector at the LHC. Top-quark jets reconstructed with the anti-$k_{t}$ algorithm with a radius parameter $R=1.0$ are selected in top-quark pair ($t\bar{t}$) events where one top quark decays semileptonically and the other hadronically, or where both top quarks decay hadronically. The top-quark jets are required to have transverse momentum $p_\mathrm{T} > 350$ GeV, yielding large samples of data events with jet $p_\mathrm{T}$ values between 350 and 600 GeV. One- and two-dimensional differential cross-sections for eight substructure variables, defined using only the charged components of the jets, are measured in a particle-level phase space by correcting for the smearing and acceptance effects induced by the detector. The differential cross-sections are compared with the predictions of several Monte Carlo simulations in which top-quark pair-production quantum chromodynamic matrix-element calculations at next-to-leading-order precision in the strong coupling constant $\alpha_\mathrm{S}$ are passed to leading-order parton shower and hadronization generators. The Monte Carlo predictions for measures of the broadness, and also the two-body structure, of the top-quark jets are found to be in good agreement with the measurements, while variables sensitive to the three-body structure of the top-quark jets exhibit some tension with the measured distributions.
A detailed map of Higgs boson interactions by the ATLAS experiment ten years after the discovery
Nature · 2022 · 371 citations
- Physics
- Particle physics
- Nuclear physics
. Since then, more than 30 times as many Higgs bosons have been recorded by the ATLAS experiment, enabling much more precise measurements and new tests of the theory. Here, on the basis of this larger dataset, we combine an unprecedented number of production and decay processes of the Higgs boson to scrutinize its interactions with elementary particles. Interactions with gluons, photons, and W and Z bosons-the carriers of the strong, electromagnetic and weak forces-are studied in detail. Interactions with three third-generation matter particles (bottom (b) and top (t) quarks, and tau leptons (τ)) are well measured and indications of interactions with a second-generation particle (muons, μ) are emerging. These tests reveal that the Higgs boson discovered ten years ago is remarkably consistent with the predictions of the theory and provide stringent constraints on many models of new phenomena beyond the standard model.
A saturated map of common genetic variants associated with human height
Nature · 2022 · 877 citations
- Genetics
- Biology
- Evolutionary biology
) account for 40% (45%) of phenotypic variance in populations of European ancestry but only around 10-20% (14-24%) in populations of other ancestries. Effect sizes, associated regions and gene prioritization are similar across ancestries, indicating that reduced prediction accuracy is likely to be explained by linkage disequilibrium and differences in allele frequency within associated regions. Finally, we show that the relevant biological pathways are detectable with smaller sample sizes than are needed to implicate causal genes and variants. Overall, this study provides a comprehensive map of specific genomic regions that contain the vast majority of common height-associated variants. Although this map is saturated for populations of European ancestry, further research is needed to achieve equivalent saturation in other ancestries.
Frequent coauthors
- 17 shared
Thomas E. Quantrille
Virginia Tech
- 1 shared
Pingyang Lu
- 1 shared
Qiang Chen
- 1 shared
Ni Chen
- 1 shared
X. Xia
- 1 shared
Yanhong H. Jin
- 1 shared
Ruzinoor Che Mat
Awards & honors
- Frank C. Vilbrandt endowed professor
- Alumni distinguished professor
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