Valerie Abadie
· Research Associate ProfessorUniversity of Chicago · Immunology and Inflammation
Active 2003–2024
About
Valerie Abadie is a Research Associate Professor at the University of Chicago in the Department of Medicine-Gastroenterology. Her research focuses on understanding how mucosal immune responses are dysregulated in intestinal inflammatory disorders. She is particularly interested in the roles of B lymphocytes, which can contribute to the pathogenesis of autoimmune disorders beyond their antibody-producing functions. Her work involves combining mouse and human studies to characterize B lymphocytes in health and disease, with a specific emphasis on Celiac Disease. Abadie's contributions include investigating the immunopathogenesis of Celiac Disease, exploring the interplay between gluten, HLA, innate and adaptive immunity, and developing mouse models to study disease mechanisms. Her research also examines immune cell networks that mediate disease tolerance, the role of cytokines such as IL-15, and the contribution of intraepithelial lymphocytes and epithelial stress to celiac disease pathology. Her work has advanced understanding of the genetic and immunological insights into celiac disease, including the development of models that mimic villous atrophy and tissue destruction. Through her extensive publication record, she has contributed significantly to the fields of mucosal immunity, autoimmune disorders, and gastrointestinal immunopathology.
Research topics
- Pathology
- Biology
- Medicine
- Immunology
Selected publications
IL-15, gluten and HLA-DQ8 drive tissue destruction in coeliac disease
Nature · 2020 · 229 citations
1st authorCorresponding- Immunology
- Medicine
- Biology
Recent grants
B cell-T cell crosstalk in celiac disease
NIH · $2.1M · 2021–2026
Center for Interdisciplinary Study of Inflammatory Intestinal DIsorders (C-IID)
NIH · $35.2M · 1996–2026
Frequent coauthors
- 27 shared
Bana Jabrì
University of Chicago
- 24 shared
Béhazine Combadière
- 20 shared
Bernard Verrier
Université Claude Bernard Lyon 1
- 18 shared
Darragh Duffy
Université Paris Cité
- 18 shared
Olivia Bonduelle
- 17 shared
Valentina Discepolo
- 13 shared
Christophe Combadière
Inserm
- 11 shared
Sarah Boudaly
Délégation Paris 7
Labs
University of Chicago Department of Medicine-GastroenterologyPI
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