About

Tianyuan Lu is an Assistant Professor in the Department of Biostatistics and Medical Informatics at the University of Wisconsin–Madison. His research focuses on genetic epidemiology and statistical genetics methodology, as well as predictive modeling. He is also engaged in biomarker and drug target discovery, contributing to advancements in biomedical informatics and clinical trials. His work aims to develop and apply statistical methods to better understand genetic factors in health and disease, supporting the discovery of new therapeutic targets and improving predictive models in medical research.

Research topics

• Biology
• Genetics
• Biochemistry
• Cancer research
• Internal medicine
• Bioinformatics
• Endocrinology
• Medicine
• Chemistry

Selected publications

• Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases

  Nature Genetics · 2023 · 950 citations

  • Biology
  • Genetics
  • Bioinformatics
  DOI

• H3K27M in Gliomas Causes a One-Step Decrease in H3K27 Methylation and Reduced Spreading within the Constraints of H3K36 Methylation

  Cell Reports · 2020 · 120 citations

  • Cancer research
  • Chemistry
  • Biology

  cell lines to investigate H3K27 methylation and its interaction with H3K36 and H3K9 modifications. We describe a "step down" effect of H3K27M on the distribution of H3K27 methylation: me3 is reduced to me2, me2 is reduced to me1, whereas H3K36me2/3 delineates the boundaries for the spread of H3K27me marks. We also observe a replacement of H3K27me2/3 silencing by H3K9me3. Using a computational simulation, we explain our observations by reduced effectiveness of PRC2 and constraints imposed on the deposition of H3K27me by antagonistic H3K36 modifications. Our work further elucidates the effects of H3K27M in gliomas as well as the general principles of deposition in H3K27 methylation.

  DOI

• Individuals with common diseases but with a low polygenic risk score could be prioritized for rare variant screening

  Genetics in Medicine · 2020 · 92 citations

  1st authorCorresponding
  • Medicine
  • Internal medicine
  • Genetics
  DOI

Frequent coauthors

• J. Brent Richards

  McGill University

  136 shared

• Celia M.T. Greenwood

  McGill University

  117 shared

• Satoshi Yoshiji

  McGill University

  95 shared

• Guillaume Butler‐Laporte

  Jewish General Hospital

  51 shared

• Sirui Zhou

  McGill University Health Centre

  51 shared

• Vincenzo Forgetta

  Jewish General Hospital

  49 shared

• Tomoko Nakanishi

  McGill University

  45 shared

• Marie Hudson

  McGill University

  35 shared

Education

• Ph.D., Biostatistics

  University of Wisconsin-Madison

  2008

• M.S., Biostatistics

  University of Wisconsin-Madison

  2003

• B.S., Biostatistics

  University of Science and Technology of China

  2001

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