Sydney B Rosen

About

Sydney Rosen, M.P.A., is a Research Professor in the Department of Global Health at the Boston University School of Public Health. She is also a Co-Director of the Health Economics and Epidemiology Research Office (HE2RO) of the University of the Witwatersrand in Johannesburg, South Africa. Her research addresses the economic consequences of the HIV/AIDS epidemic, focusing on the outcomes, costs, cost-effectiveness, and benefits of HIV and TB care and treatment interventions and models of service delivery. She is the principal investigator of multiple studies supported by USAID, NIH, and foundations, and has extensive work experience in South Africa, Zambia, Malawi, and Kenya. Her technical training is in policy analysis and applied economics, and she holds a BA magna cum laude from Harvard University and an MPA from the Kennedy School of Government at Harvard.

Research topics

• Medicine
• Family medicine
• Internal medicine
• Pediatrics
• Physical therapy
• Virology
• Environmental health
• Nursing
• Marketing
• Medical physics

Selected publications

• Retention in care and viral suppression in differentiated service delivery models for HIV treatment delivery in sub‐Saharan Africa: a rapid systematic review

  Journal of the International AIDS Society · 2020 · 157 citations

  Senior authorCorresponding

  INTRODUCTION: Differentiated service delivery (DSD) models for antiretroviral treatment (ART) for HIV are being scaled up in the expectation that they will better meet the needs of patients, improve the quality and efficiency of treatment delivery and reduce costs while maintaining at least equivalent clinical outcomes. We reviewed the recent literature on DSD models to describe what is known about clinical outcomes. METHODS: We conducted a rapid systematic review of peer-reviewed publications i…

  DOI

• The revolving door of HIV care: Revising the service delivery cascade to achieve the UNAIDS 95-95-95 goals

  PLoS Medicine · 2021 · 152 citations

  Peter Ehrenkranz and co-authors present a cyclical cascade of care for people with HIV infection, aiming to facilitate assessment of outcomes.

  DOI

• Change in body weight and risk of hypertension after switching from efavirenz to dolutegravir in adults living with HIV: evidence from routine care in Johannesburg, South Africa

  EClinicalMedicine · 2023 · 97 citations

  Background: The integrase strand transfer inhibitor (INSTI) dolutegravir is recommended in World Health Organization guidelines, but is associated with weight gain. We evaluated weight change in patients switching from efavirenz to dolutegravir in first-line antiretroviral therapy (ART) in Johannesburg, South Africa. Methods: We conducted a prospective cohort study of adults (≥16 years) of black African ancestry with HIV who initiated ART between January 2010-December 2020. Patients were propens…

  DOI

• Multimonth dispensing of up to 6 months of antiretroviral therapy in Malawi and Zambia (INTERVAL): a cluster-randomised, non-blinded, non-inferiority trial

  The Lancet Global Health · 2021 · 79 citations

  Senior authorCorresponding

  BACKGROUND: Facility-based, multimonth dispensing of antiretroviral therapy (ART) for HIV could reduce burdens on patients and providers and improve retention in care. We assessed whether 6-monthly ART dispensing was non-inferior to standard of care and 3-monthly ART dispensing. METHODS: We did a pragmatic, cluster-randomised, unblinded, non-inferiority trial (INTERVAL) at 30 health facilities in Malawi and Zambia. Eligible participants were aged 18 years or older, HIV-positive, and were clinica…

  DOI

• A clinical algorithm for same-day HIV treatment initiation in settings with high TB symptom prevalence in South Africa: The SLATE II individually randomized clinical trial

  PLoS Medicine · 2020 · 45 citations

  Senior authorCorresponding

  BACKGROUND: Many countries encourage same-day initiation of antiretroviral therapy (ART), but evidence on eligibility for same-day initiation, how best to implement it, and its impact on outcomes remains scarce. Building on the Simplified Algorithm for Treatment Eligibility (SLATE) I trial, in which nearly half of participants were ineligible for same-day initiation mainly because of TB symptoms, the study evaluated the revised SLATE II algorithm, which allowed same-day initiation for patients w…

  DOI

Recent grants

• NIH Grant U01AI100015

  NIH · $1.2M · 2017

Frequent coauthors

• Matthew P. Fox

  University of the Witwatersrand

  367 shared

• Lawrence Long

  Boston University

  208 shared

• Alana T. Brennan

  Africa Health Research Institute

  192 shared

• Ian Sanne

  Advanced Biological Laboratories (Luxembourg)

  173 shared

• Brooke E. Nichols

  Foundation for Innovative New Diagnostics

  127 shared

• Bruce A. Larson

  Boston University

  106 shared

• Gesine Meyer‐Rath

  Boston University

  98 shared

• Mariet Benade

  Amsterdam University Medical Centers

  75 shared

Labs

• Admissions TeamPI

Education

• Master of Public Administration (MPA), Kennedy School of Government

  Harvard University

  1995

• BA Magna Cum Laude

  Harvard University

  1987

Similar researchers at Boston University

• Charles R Horsburghh-96
• Elaine O. Nsoesieh-55
• William B. MacLeodh-53