Steven A. Siegelbaum

Gating movements and ion permeation in HCN4 pacemaker channels

Molecular Cell · 2021 · 94 citations

Enhanced excitability of the hippocampal CA2 region and its contribution to seizure activity in a mouse model of temporal lobe epilepsy

Neuron · 2022 · 78 citations

Tuned geometries of hippocampal representations meet the computational demands of social memory

Neuron · 2024-02-20 · 71 citations

Postsynaptic integrative properties of dorsal CA1 pyramidal neuron subpopulations

Journal of Neurophysiology · 2020-01-22 · 34 citations

The population activity of CA1 pyramidal neurons (PNs) segregates along anatomical axes with different behaviors, suggesting that CA1 PNs are functionally subspecialized based on somatic location. In dorsal CA1, spatial encoding is biased toward CA2 (CA1c) and in deep layers of the radial axis. In contrast, nonspatial coding peaks toward subiculum (CA1a) and in superficial layers. While preferential innervation by spatial vs. nonspatial input from entorhinal cortex (EC) may contribute to this sp…

Synaptic Organization of Anterior Olfactory Nucleus Inputs to Piriform Cortex

Journal of Neuroscience · 2020-10-28 · 27 citations

Odors activate distributed ensembles of neurons within the piriform cortex, forming cortical representations of odor thought to be essential to olfactory learning and behaviors. This odor response is driven by direct input from the olfactory bulb, but is also shaped by a dense network of associative or intracortical inputs to piriform, which may enhance or constrain the cortical odor representation. With optogenetic techniques, it is possible to functionally isolate defined inputs to piriform co…