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Stephen P. Goff

Stephen P. Goff

· Higgins Professor of Biochemistry and Molecular Biophysics, Professor of Microbiology & Immunology

Columbia University · Biochemistry and Molecular Biophysics

Active 1973–2025

h-index123
Citations48.0k
Papers50751 last 5y
Funding$53.4M

Academic metrics are sourced from OpenAlex and public funding records; values may differ from Google Scholar.

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About

Stephen P. Goff, PhD, is the Higgins Professor of Biochemistry and Molecular Biophysics and a Professor of Microbiology & Immunology at Columbia University Irving Medical Center. His research has focused on viruses and their interactions with the host throughout his career. Over the past three decades, his laboratory has concentrated on the replication of mammalian retroviruses, including Moloney murine leukemia virus and HIV-1, aiming to define the functions of viral gene products and identify host proteins involved in viral interactions. His work has significantly contributed to understanding all aspects of the viral life cycle, including the characterization of host restriction factors such as ZAP, which degrades viral mRNAs to block gene expression of various viruses, and ZFP809, which recognizes and silences retroviral DNA in embryonic stem cells. Goff's research also explores chromatinization and silencing mechanisms of incoming retroviral DNA, as well as the role of endogenous viral proteins in tumor immunology. He is dedicated to training students and fellows, having mentored approximately thirty-five PhD students and an equal number of postdoctoral fellows, many of whom have gone on to prominent positions in academia, research institutions, and industry.

Research topics

  • Virology
  • Medicine
  • Biology
  • Genetics
  • Biochemistry
  • Immunology
  • Political Science
  • Pathology
  • Computational biology
  • Chemistry

Selected publications

Recent grants

Frequent coauthors

  • Guangxia Gao

    Institute of Biophysics

    63 shared

  • Sharon Boast

    Columbia University

    55 shared

  • Baojie Li

    Shanghai Jiao Tong University

    46 shared

  • Yosef Sabo

    Columbia University

    39 shared

  • Peter Gouras

    Columbia University

    33 shared

  • David Baltimore

    31 shared

  • Marianna Orlova

    McGill University

    30 shared

  • Yuanyu Hu

    29 shared

Labs

Education

  • Fellow, Biology

    Massachusetts Institute of Technology

    1981

  • PhD, Biochemistry

    Stanford University School of Medicine

    1978

Awards & honors

  • Irma T. Hirschl Career Development Award (1982-1986)
  • Searle Scholarship Award (1982-1985)
  • Harold and Golden Lamport Research Award, Columbia Univ. (19…
  • MERIT award, NCI (1990, 2003)
  • Dean's Distinguished Lecture in the Basic Sciences, Columbia…

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