Wayne A Hendrickson

About

Dr. Wayne A. Hendrickson is the Principal Investigator of the Hendrickson Lab at Columbia University Irving Medical Center, where his research focuses on the structure and function of biological molecules. His laboratory employs advanced techniques such as x-ray crystallography, cryogenic electron microscopy (cryo-EM), and biochemical analyses to study biological macromolecules at atomic resolution. Dr. Hendrickson and his colleagues have made significant advances in diffraction methods, including stereochemically restrained refinement, phase evaluation from anomalous diffraction, the use of selenomethionyl proteins, and the development of synchrotron instrumentation. These innovations have been instrumental in establishing structural biology as a major discipline within modern biology and molecular medicine. The Hendrickson Lab applies these technologies to investigate a variety of biological systems, including membrane receptors and cellular signaling pathways, viral proteins and HIV infection mechanisms, molecular chaperones and protein folding processes, as well as structural genomics of membrane proteins. Through these studies, Dr. Hendrickson's work contributes to a deeper understanding of the molecular basis of biological function and disease.

Research topics

• Biochemistry
• Biology
• Chemistry
• Biophysics
• Cell biology
• Stereochemistry
• Crystallography
• Botany

Selected publications

• Structure of human GABAB receptor in an inactive state

  Nature · 2020 · 98 citations

  DOI

• Gating movements and ion permeation in HCN4 pacemaker channels

  Molecular Cell · 2021 · 94 citations

  PublisherOA PDFDOI

• Structure and activity of SLAC1 channels for stomatal signaling in leaves

  Proceedings of the National Academy of Sciences · 2021 · 68 citations

  SLAC1 structure has its pores closed, in a basal state, spring loaded by phenylalanyl residues in high-energy conformations. SLAC1 phosphorylation fine-tunes an equilibrium between basal and activated SLAC1 trimers, thereby controlling the degree of stomatal opening.

  DOI

• Symmetric activation and modulation of the human calcium-sensing receptor

  Proceedings of the National Academy of Sciences · 2021 · 63 citations

  levels and contributes to nutrient-dependent maintenance and metabolism of diverse organs. Allosteric modulation of the CaS receptor corrects disorders of calcium homeostasis. Here, we report the cryogenic-electron microscopy reconstructions of a near-full-length CaS receptor in the absence and presence of allosteric modulators. Activation of the homodimeric CaS receptor requires a break in the transmembrane 6 (TM6) helix of each subunit, which facilitates the formation of a TM6-mediated homodim…

  PublisherOA PDFDOI

• Metal‐Mediated DNA Nanotechnology in 3D: Structural Library by Templated Diffraction

  Advanced Materials · 2023-06-02 · 29 citations

  articleOpen access

  ions between pyrimidine:pyrimidine pairs with the promise of nanoelectronics. Rational design of mmDNA nanomaterials is impractical without a complete lexical and structural description. Here, the programmability of structural DNA nanotechnology toward its founding mission of self-assembling a diffraction platform for biomolecular structure determination is explored. The tensegrity triangle is employed to build a comprehensive structural library of mmDNA pairs via X-ray diffraction and generaliz…

  PublisherOA PDFDOI

Recent grants

• NIH Grant R37GM034102

  NIH · $3.0M · 2004

• NIH Grant U54GM095315

  NIH · $30.7M · 2016

• NIH Grant R01HL034434

  NIH · $136k · 1990

Frequent coauthors

• Peter D. Kwong

  National Institutes of Health

  151 shared

• Richard T. Wyatt

  Scripps Institution of Oceanography

  114 shared

• Joseph Sodroski

  Dana-Farber Cancer Institute

  109 shared

• Qun Liu

  China Agricultural University

  98 shared

• James E. Robinson

  51 shared

• Raymond W. Sweet

  41 shared

• Filippo Mancia

  36 shared

• William E. Royer

  University of Massachusetts Chan Medical School

  35 shared

Labs

• Hendrickson LabPI

Education

• B.A.

  University of Wisconsin at River Falls

• Ph.D., biophysics

  Johns Hopkins University

Awards & honors

• Ewald Prize, The International Union of Crystallography (IUC…
• Harvey Prize, Technion - Israel Institute of Technology (200…
• Canada Gairdner International Award (2003)
• Compton Award, Advanced Photon Source of Argonne National La…
• Doctor of Science honoris causa, Mount Sinai School of Medic…

Similar researchers at Columbia University

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• Stephen P. Goffh-123