Stephen Bondy

About

Stephen Bondy is a Professor of Neuroscience at the Center for Occupational and Environmental Health, University of California, Irvine, a position he has held since 1985. He holds an M.A. from Cambridge University and a Ph.D. in Biochemistry from the University of Birmingham, UK, obtained in 1962. His academic career includes positions at Columbia University, UCLA, University of Colorado, and the National Institute for Environmental Health Sciences, where he served as Head of the Neurochemistry Section. Dr. Bondy has authored approximately 400 articles and reviews, reflecting his extensive contributions to the field. His research primarily focuses on the mechanistic processes by which environmental and nutritional agents influence the rate of brain aging. He has been studying the effects of melatonin on brain aging since 2001, with particular interest in melatonin's role as a neuromodulator that optimizes immune responses to external stimuli while reducing chronic inflammation in the aging brain. His work demonstrates that melatonin can regulate immune function and inhibit tumor formation in aging mice. Additionally, he investigates how low-level ingestion of aluminum salts may promote age-related chronic inflammation, accelerating neurodegenerative diseases. Overall, his research emphasizes the role of exogenous factors in either enhancing or slowing age-related inflammatory events and neurodegeneration. Dr. Bondy's research also explores the contribution of inflammatory…

Research topics

• Biology
• Immunology
• Medicine
• Neuroscience
• Internal medicine
• Biochemistry
• Toxicology
• Chemistry
• Evolutionary biology

Selected publications

• The Hormesis Concept: Strengths and Shortcomings

  Biomolecules · 2023 · 60 citations

  1st authorCorresponding

  Hormesis implies that the effects of various materials or conditions that organisms are exposed to, may not have linear dose-response characteristics but rather, can be biphasic. Thus the response to a low dose of a stressor may be the opposite to that occurring at higher doses. Such a dual response is postulated for many toxicants and physical conditions and may involve a beneficial adaptive response. Such a non-linear effect is undoubtedly present in many useful pharmacological and nutraceutic…

  PublisherOA PDFDOI

• Melatonin and Regulation of Immune Function: Impact on Numerous Diseases

  Current Aging Science · 2020 · 35 citations

  1st authorCorresponding

  Melatonin is well known as a neuroendocrine hormone that promotes sleep. However, the many other attributes of melatonin are less apparent and not as widely appreciated. The purpose of this review is to summarize the qualities of melatonin relating to immune function. The relevance of melatonin in partially or wholly restoring optimal function, in a series of disorders related to immune dysfunction, is addressed in this report. This includes the potential relief of both autoimmune diseases and m…

  PublisherOA PDFDOI

• Metal toxicity and neuroinflammation

  Current Opinion in Toxicology · 2021-04-02 · 31 citations

  articleOpen access1st authorCorresponding
  PublisherOA PDFDOI

• Mitochondrial Dysfunction as the Major Basis of Brain Aging

  Biomolecules · 2024-03-26 · 27 citations

  articleOpen access1st authorCorresponding

  The changes in the properties of three biological events that occur with cerebral aging are discussed. These adverse changes already begin to develop early in mid-life and gradually become more pronounced with senescence. Essentially, they are reflections of the progressive decline in effectiveness of key processes, resulting in the deviation of essential biochemical trajectories to ineffective and ultimately harmful variants of these programs. The emphasis of this review is the major role playe…

  PublisherOA PDFDOI

• Distinctive cellular response to aluminum based adjuvants

  Environmental Toxicology and Pharmacology · 2020 · 27 citations

  DOI

Recent grants

• NIH Grant R01ES004071

  NIH · $392k · 1990

• NIH Grant R01ES007992

  NIH · $2.9M · 2007

• NIH Grant R01AG016794

  NIH · $3.0M · 2010

Frequent coauthors

• Kedar N. Prasad

  34 shared

• Arezoo Campbell

  Western University of Health Sciences

  29 shared

• Carl LeBel

  Frequency Therapeutics (United States)

  22 shared

• Debomoy K. Lahiri

  Indiana University School of Medicine

  22 shared

• Syed F. Ali

  University of Saint Joseph

  18 shared

• Edward Sharman

  University of California, Irvine

  17 shared

• Marilyn E. Harrington

  University of Colorado Denver

  16 shared

• Shirley X. Guo

  University of California, Irvine

  15 shared

Labs

• Center for Occupational and Environmental Health, University of California, IrvinePI

Education

• Ph.D., Public Health

  University of California, Los Angeles

  1990

• M.S., Public Health

  University of California, Los Angeles

  1985

• B.A., Biology

  University of California, Los Angeles

  1983

Similar researchers at University of California, Irvine

• Charles Limolih-66
• Jun Wuh-51
• Masashi Kitazawah-48