Charles Limoli

About

Charles L Limoli is a Professor of Radiation Oncology at the School of Medicine at the University of California, Irvine. His research focuses on stem cell mechanisms regulating stress responses in compromised tissue beds, particularly how stem cells can be used to mitigate radiation- and chemotherapy-induced normal tissue injury in the brain. His work has evolved from a formal training in radiation biology and studies investigating radiation-induced genomic instability and redox stress biology. Significant efforts are directed toward elucidating the molecular and biochemical mechanisms regulating stem cell responses within irradiated microenvironments, with a particular emphasis on understanding how stem cell transplants can improve cognition after irradiation and chemotherapy, aiming to develop clinical interventions for long-term cognitive health in cancer survivors. Additionally, his long-standing interests include exploring the adverse effects of space radiation, using in vitro and in vivo models to define biological responses to charged particle irradiation, and assessing the risks of radiation exposure to human health, such as carcinogenesis, neurodegeneration, and cognitive performance.

Research topics

• Medicine
• Oncology
• Computer Science
• Internal medicine
• Cancer research
• Psychiatry
• Pathology
• Medical physics
• Family medicine
• Radiology

Selected publications

• Hypofractionated FLASH-RT as an Effective Treatment against Glioblastoma that Reduces Neurocognitive Side Effects in Mice

  Clinical Cancer Research · 2020 · 325 citations

  PURPOSE: Recent data have shown that single-fraction irradiation delivered to the whole brain in less than tenths of a second using FLASH radiotherapy (FLASH-RT), does not elicit neurocognitive deficits in mice. This observation has important clinical implications for the management of invasive and treatment-resistant brain tumors that involves relatively large irradiation volumes with high cytotoxic doses. EXPERIMENTAL DESIGN: Therefore, we aimed at simultaneously investigating the antitumor ef…

  DOI

• Neuroprotection of Radiosensitive Juvenile Mice by Ultra-High Dose Rate FLASH Irradiation

  Cancers · 2020 · 131 citations

  Senior authorCorresponding

  ) neurons and increased neuroinflammation, adverse effects that were not found with FLASH-RT. Our data point to a potentially innovative treatment modality that is able to spare, if not prevent, many of the side effects associated with long-term treatment that disrupt the long-term cognitive and emotional well-being of medulloblastoma survivors.

  DOI

• Understanding High-Dose, Ultra-High Dose Rate, and Spatially Fractionated Radiation Therapy

  International Journal of Radiation Oncology*Biology*Physics · 2020 · 122 citations

  Senior authorCorresponding
  DOI

• A second space age spanning omics, platforms and medicine across orbits

  Nature · 2024-06-11 · 49 citations

  reviewOpen access
  PublisherOA PDFDOI

• FLASH: New intersection of physics, chemistry, biology, and cancer medicine

  Reviews of Modern Physics · 2024-09-19 · 38 citations

  articleOpen accessSenior author

  . These observations define the FLASH effect. The FLASH effect has been reported to occur when using single or hypofractionated dose regimens in several experimental animal models (mice, rat, zebrafish, pig, and cats) and in multiple organs (lung, skin, gut, and brain) by numerous groups worldwide. Note that the FLASH effect has been demonstrated with electron, photon, and hadron (proton and heavier ion) beams. The current status and future technological development are reviewed, with an emphasi…

  PublisherOA PDFDOI

Recent grants

• Mechanisms underlying radiation-and chemotherapy induced cognitive impairment.

  NIH · $2.8M · 2016–2021

• Improving pediatric brain tumor treatments using FLASH radiotherapy

  NIH · $2.2M · 2021–2027

• Dosimetry, Physics & Modeling Core

  NIH · $4.3M · 2020–2025

Frequent coauthors

• Munjal M. Acharya

  University of California, Irvine

  101 shared

• Marie‐Catherine Vozenin

  University Hospital of Geneva

  76 shared

• Erich Giedzinski

  75 shared

• Janet E. Baulch

  58 shared

• John R. Fike

  Montana State University

  56 shared

• Benoît Petit

  University of Lausanne

  48 shared

• Vipan K. Parihar

  42 shared

• Barrett D. Allen

  University of California, Irvine

  42 shared

Education

• Ph.D.

  University of California, Irvine

Similar researchers at University of California, Irvine

• Stephen Bondyh-58
• Jun Wuh-51
• Masashi Kitazawah-48