About
Welcome to the Oh lab at UCSD! Our research group is part of the Department of Physics and the Department of Cellular And Molecular Medicine at the University of California, San Diego. We are interested in how life controls its physical properties and are currently focusing on single-cell regulation of protein and lipid mass, volume, and density. We develop cutting-edge label-free optical microscopy tools including quantitative phase microscopy and nonlinear optical microscopy to explore these phenomenon in cells, small model organisms, and tissues.
Research topics
- Genetics
- Biology
- Pharmacology
- Computational biology
- Cell biology
- Cancer research
- Chemistry
Selected publications
Enhancer release and retargeting activates disease-susceptibility genes
Nature · 2021 · 150 citations
1st authorCorresponding- Genetics
- Biology
- Computational biology
Cell Reports · 2020 · 40 citations
- Cancer research
- Biology
- Chemistry
Cisplatin is an antineoplastic drug administered at suboptimal and intermittent doses to avoid life-threatening effects. Although this regimen shortly improves symptoms in the short term, it also leads to more malignant disease in the long term. We describe a multilayered analysis ranging from chromatin to translation-integrating chromatin immunoprecipitation sequencing (ChIP-seq), global run-on sequencing (GRO-seq), RNA sequencing (RNA-seq), and ribosome profiling-to understand how cisplatin confers (pre)malignant features by using a well-established ovarian cancer model of cisplatin exposure. This approach allows us to segregate the human transcriptome into gene modules representing distinct regulatory principles and to characterize that the most cisplatin-disrupted modules are associated with underlying events of super-enhancer plasticity. These events arise when cancer cells initiate without ultimately ending the program of drug-stimulated death. Using a PageRank-based algorithm, we predict super-enhancer regulator ISL1 as a driver of this plasticity and validate this prediction by using CRISPR/dCas9-KRAB inhibition (CRISPRi) and CRISPR/dCas9-VP64 activation (CRISPRa) tools. Together, we propose that cisplatin reprograms cancer cells when inducing them to undergo near-to-death experiences.
Frequent coauthors
- 39 shared
Michael G. Rosenfeld
University of California, San Diego
- 29 shared
Qi Ma
Xinjiang Medical University
- 27 shared
Wenbo Li
- 27 shared
Kenneth A. Ohgi
University of California, San Diego
- 17 shared
Daria Merkurjev
- 17 shared
Sreejith J. Nair
Georgetown University Medical Center
- 17 shared
Xiaoyuan Song
University of Science and Technology of China
- 15 shared
Chengyu Liang
Labs
Education
- 2010
Ph.D., Physics
Massachusetts Institute of Technology
Similar researchers at University of California, San Diego
- Resume-aware match score
- Save to shortlist
- AI-drafted outreach
See your match with Seungeun Oh
PhdFit ranks faculty by your research interests, methods, and publications — grounded in their actual work, not templates.
- Free to start
- No credit card
- 30-second signup