Michael (Geoff) Rosenfeld

About

Michael (Geoff) Rosenfeld is a Professor of Medicine at UC San Diego, with a research focus on the regulatory landscape of the aging human ovary, immune and beta cell dysregulation underlying type 1 diabetes, and the roles of HSV1 transcripts in Alzheimer's disease pathogenesis and therapy. His work involves multi-omics analyses, gene regulation, enhancer codes, and chromosomal architecture to understand complex biological processes and disease mechanisms. Rosenfeld has contributed to advancing knowledge in gene transcription, enhancer specificity, and genome architecture, with numerous funded projects supported by NIH grants. His research integrates molecular biology, genetics, and translational approaches to address critical questions in aging, neurodegeneration, and cancer.

Research topics

• Genetics
• Cell biology
• Biology
• Computational biology
• Medicine
• Internal medicine
• Cancer research

Selected publications

• A transcriptional switch governs fibroblast activation in heart disease

  Nature · 2021 · 221 citations

  DOI

• Enhancer release and retargeting activates disease-susceptibility genes

  Nature · 2021 · 150 citations

  Senior authorCorresponding
  DOI

• EGFR promotes ALKBH5 nuclear retention to attenuate N6-methyladenosine and protect against ferroptosis in glioblastoma

  Molecular Cell · 2023-11-17 · 63 citations

  articleOpen access
  PublisherOA PDFDOI

• Molecular and genetic insights into human ovarian aging from single-nuclei multi-omics analyses

  Nature Aging · 2024-11-22 · 62 citations

  articleOpen access

  The ovary is the first organ to age in the human body, affecting both fertility and overall health. However, the biological mechanisms underlying human ovarian aging remain poorly understood. Here we present a comprehensive single-nuclei multi-omics atlas of four young (ages 23–29 years) and four reproductively aged (ages 49–54 years) human ovaries. Our analyses reveal coordinated changes in transcriptomes and chromatin accessibilities across cell types in the ovary during aging, notably mTOR si…

  PublisherDOI

• Enhancer–promoter specificity in gene transcription: molecular mechanisms and disease associations

  Experimental & Molecular Medicine · 2024-04-25 · 38 citations

  reviewOpen access

  Although often located at a distance from their target gene promoters, enhancers are the primary genomic determinants of temporal and spatial transcriptional specificity in metazoans. Since the discovery of the first enhancer element in simian virus 40, there has been substantial interest in unraveling the mechanism(s) by which enhancers communicate with their partner promoters to ensure proper gene expression. These research efforts have benefited considerably from the application of increasing…

  PublisherOA PDFDOI

Recent grants

• Phase Separation: A New Phase in Decoding Enhancer-dependent Critical Transcriptional Programs by Nuclear Receptors

  NIH · $4.2M · 1982–2025

• Chromosomal Boundary Alterations Driving Transcriptional Dysregulation in Brain Disorders

  NIH · $2.4M · 2016–2022

• NIH Grant R01NS048243

  NIH · $903k · 2008

Frequent coauthors

• Christopher K. Glass

  University of California, San Diego

  244 shared

• Kenneth A. Ohgi

  University of California, San Diego

  146 shared

• Ronald M. Evans

  Salk Institute for Biological Studies

  137 shared

• David W. Rose

  The University of Texas at Tyler

  106 shared

• Dimple Notani

  National Centre for Biological Sciences

  91 shared

• Ranveer Singh Jayani

  86 shared

• Bogdan Paşaniuc

  University of California, Los Angeles

  82 shared

• Wenbo Li

  82 shared

Education

• Ph.D., Molecular and Computational Biology

  University of California, San Diego

  1996

• M.S., Molecular and Computational Biology

  University of California, San Diego

  1992

• B.S., Biology

  University of California, San Diego

  1990

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