Christopher Glass

About

Professor Christopher Glass leads the Glass Laboratory at UCSD, where the research focuses on understanding the transcriptional mechanisms that regulate the development and function of macrophages. Macrophages are critical cells involved in immunity and inflammatory diseases. The laboratory's current efforts aim to elucidate the biochemical and biological roles of sequence-specific transcription factors and their associated co-regulators at both gene-specific and genome-wide levels. To achieve this, the lab employs a combination of biochemical, cellular, and genetic model systems, including macrophage-specific knockouts, microarray technologies, massively parallel sequencing, and bioinformatics approaches. These methodologies are used to unravel how specific factors contribute to the development of specialized macrophage functions in immunity and the pathogenesis of inflammatory diseases. The research interests of the Glass Laboratory include investigating enhancer selection and function, particularly how macrophage lineage-determining factors such as PU.1 prime enhancers for subsequent actions of signal-dependent transcription factors like NFkB and members of the nuclear receptor superfamily. The lab also uses genome-wide approaches to define how developmental origin and tissue environment influence macrophage functions in both mouse and human models in health and disease contexts. Additionally, the lab exploits natural genetic variation from different inbred mouse strains…

Research topics

• Biology
• Genetics
• Cell biology
• Medicine
• Pathology
• Neuroscience
• Computer Science
• Immunology
• Sociology
• Cancer research

Selected publications

• Microglia states and nomenclature: A field at its crossroads

  Neuron · 2022 · 1828 citations

  PublisherOA PDFDOI

• Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics

  Circulation Research · 2020 · 563 citations

  RATIONALE: Atherosclerotic lesions are known for their cellular heterogeneity, yet the molecular complexity within the cells of human plaques has not been fully assessed. OBJECTIVE: Using single-cell transcriptomics and chromatin accessibility, we gained a better understanding of the pathophysiology underlying human atherosclerosis. METHODS AND RESULTS: T cells showed activation-based subclasses, each with a gradual decline from a cytotoxic to a more quiescent phenotype. Myeloid cells included 2…

  DOI

• Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis

  Immunity · 2020 · 422 citations

  Senior authorCorresponding
  DOI

• Neuroinflammation in Alzheimer disease

  Nature reviews. Immunology · 2024-12-09 · 373 citations

  reviewOpen access
  PublisherOA PDFDOI

• Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer’s patients

  Cell stem cell · 2021 · 244 citations

  PublisherOA PDFDOI

Recent grants

• Mechanisms controlling human microglia gene expression

  NIH · $4.3M · 2016–2026

• NIH Grant U19DK062434

  NIH · $51.6M · 2012

• Gene Networks controlling macrophage-adipocyte interactions in insulin

  NIH · $33.0M · 2007–2018

Frequent coauthors

• Michael G. Rosenfeld

  University of California, San Diego

  244 shared

• David W. Rose

  The University of Texas at Tyler

  73 shared

• Mitchell A. Lazar

  University of Pennsylvania

  59 shared

• Johannes C. M. Schlachetzki

  University of California, San Diego

  56 shared

• Frank J. Gonzalez

  Colciencias

  55 shared

• Liliane Michalik

  University of Lausanne

  53 shared

• Johan Auwerx

  École Polytechnique Fédérale de Lausanne

  52 shared

• Christopher Benner

  University of California, San Diego

  52 shared

Education

• Ph.D., Molecular Biology

  University of California, San Diego

  1990

• B.S., Biology

  University of California, San Diego

  1985

Similar researchers at University of California, San Diego

• Richard Kolodnerh-146
• Lawrence Goldsteinh-123
• Jeffrey Eskoh-99