Scott Randell

About

Scott Randell is an Associate Professor at the University of North Carolina School of Medicine. His research focuses on the identification of airway epithelial stem cells, innate immunity in the airway, and the pathophysiology of post-lung transplant ischemia reperfusion injury and bronchiolitis obliterans syndrome. His laboratory is dedicated to exploring basic cell biology questions as they relate to clinical lung disease problems. Recently, his work has contributed to the NIH NHLBI Lung Repair and Regeneration Consortium, where he examines factors regulating airway and distal lung epithelial growth and differentiation, with an emphasis on the regulation of stemness and differentiation of key epithelial cell types. He also contributes to team science efforts on cystic fibrosis and aerodigestive cancers. Additionally, he directs a tissue procurement and cell culture Core that provides primary human lung cells and other resources locally, nationally, and internationally. Randell is the inaugural co-director of the Respiratory Block and serves as the “Physiology Coil” in the UNC Translational Educational Curriculum for medical students. He also teaches in several graduate-level courses.

Research topics

• Biology
• Genetics
• Cancer research
• Virology
• Immunology
• Internal medicine
• Medicine
• Molecular biology
• Cell biology
• Computational biology

Selected publications

• SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract

  Cell · 2020 · 1656 citations

  DOI

• SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo

  Science · 2020 · 998 citations

  The spike aspartic acid-614 to glycine (D614G) substitution is prevalent in global severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains, but its effects on viral pathogenesis and transmissibility remain unclear. We engineered a SARS-CoV-2 variant containing this substitution. The variant exhibits more efficient infection, replication, and competitive fitness in primary human airway epithelial cells but maintains similar morphology and in vitro neutralization properties, compared…

  DOI

• Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte Dysfunction

  Cell stem cell · 2020 · 422 citations

  PublisherOA PDFDOI

• Content and Performance of the MiniMUGA Genotyping Array: A New Tool To Improve Rigor and Reproducibility in Mouse Research

  Genetics · 2020 · 109 citations

  individuals across a variety of sample types, new markers that expand the utility of reduced complexity crosses to genetic backgrounds other than C57BL/6, and the robust detection of 17 genetic constructs. We provide preliminary evidence that the array can be used to identify both partial sex chromosome duplication and mosaicism, and that diagnostic SNPs can be used to determine how long inbred mice have been bred independently from the relevant main stock. We conclude that MiniMUGA is a valuabl…

  DOI

• Targeted replacement of full-length CFTR in human airway stem cells by CRISPR-Cas9 for pan-mutation correction in the endogenous locus

  Molecular Therapy · 2021 · 66 citations

  PublisherOA PDFDOI

Recent grants

• NIH Grant RC1HL100108

  NIH · $1000k · 2012

• Core B: Sample Acquisition and Repository Core

  NIH · $33.0M · 2020

• An Integrated Approach to Airway Epithelial Repair and Regeneration

  NIH · $3.3M · 2012–2017

Frequent coauthors

• Richard C. Boucher

  University of North Carolina at Chapel Hill

  172 shared

• Kenichi Okuda

  Lung Institute

  102 shared

• Wanda K. O’Neal

  University of North Carolina at Chapel Hill

  97 shared

• Hong Dang

  Lung Institute

  96 shared

• Rodney C. Gilmore

  Lung Institute

  85 shared

• Takafumi Kato

  85 shared

• Rhianna E. Lee

  79 shared

• Teresa Mascenik

  Lung Institute

  78 shared

Education

• Ph.D., Toxicology

  University of North Carolina at Chapel Hill

  1994

• M.S., Toxicology

  University of North Carolina at Chapel Hill

  1991

• B.S., Toxicology

  University of North Carolina at Chapel Hill

  1988

Similar researchers at University of North Carolina at Chapel Hill

• Paul Watkinsh-107
• Alexander Tropshah-93
• Beverly Kollerh-91