Sangjin Kim

About

Sangjin Kim is an Assistant Professor in the Departments of Physics and Biomedical and Translational Sciences at the University of Illinois. He is also an affiliate of the Carl R. Woese Institute for Genomic Biology. His research focuses on the molecular biology and biophysics of RNA, particularly investigating the mechanisms of transcription and mRNA kinetics in bacterial systems such as Escherichia coli and Caulobacter crescentus. Kim's work involves studying RNA-dependent RNA polymerase, reverse transcriptase, RNA polymerase, and DNA supercoiling, with an emphasis on understanding gene synthesis and transcription dynamics. His research employs advanced techniques including single-particle tracking, fluorescence microscopy, and single-molecule fluorescence in situ hybridization to probe the spatial and temporal kinetics of mRNA. Kim has contributed to the understanding of how DNA supercoiling influences collective modes of gene synthesis and how transcription processes are coordinated with mRNA decay and translation. He has been recognized with honors such as the Searle Scholar Award in 2020 and the Kavli Frontiers of Science Fellowship in 2022.

Research topics

• Biology
• Cancer research
• Medicine
• Internal medicine
• Immunology
• Biochemistry
• Endocrinology
• Cell biology

Selected publications

• FOXM1 regulates glycolysis and energy production in multiple myeloma

  Oncogene · 2022 · 56 citations

  The transcription factor, forkhead box M1 (FOXM1), has been implicated in the natural history and outcome of newly diagnosed high-risk myeloma (HRMM) and relapsed/refractory myeloma (RRMM), but the mechanism with which FOXM1 promotes the growth of neoplastic plasma cells is poorly understood. Here we show that FOXM1 is a positive regulator of myeloma metabolism that greatly impacts the bioenergetic pathways of glycolysis and oxidative phosphorylation (OxPhos). Using FOXM1-deficient myeloma cells…

  DOI

• Suppression of Tumor Growth, Metastasis, and Signaling Pathways by Reducing FOXM1 Activity in Triple Negative Breast Cancer

  Cancers · 2020 · 41 citations

  Metastasis-related complications account for the overwhelming majority of breast cancer mortalities. Triple negative breast cancer (TNBC), the most aggressive breast cancer subtype, has a high propensity to metastasize to distant organs, leading to poor patient survival. The forkhead transcription factor, FOXM1, is especially upregulated and overexpressed in TNBC and is known to regulate multiple signaling pathways that control many key cancer properties, including proliferation, invasiveness, s…

  DOI

• Contrasting activities of estrogen receptor beta isoforms in triple negative breast cancer

  Breast Cancer Research and Treatment · 2020 · 33 citations

  DOI

• Endothelial ERα promotes glucose tolerance by enhancing endothelial insulin transport to skeletal muscle

  Nature Communications · 2023-08-17 · 22 citations

  articleOpen access

  The estrogen receptor (ER) designated ERα has actions in many cell and tissue types that impact glucose homeostasis. It is unknown if these include mechanisms in endothelial cells, which have the potential to influence relative obesity, and processes in adipose tissue and skeletal muscle that impact glucose control. Here we show that independent of impact on events in adipose tissue, endothelial ERα promotes glucose tolerance by enhancing endothelial insulin transport to skeletal muscle. Endothe…

  PublisherOA PDFDOI

• NB compounds are potent and efficacious FOXM1 inhibitors in high-grade serous ovarian cancer cells

  Journal of Ovarian Research · 2024-05-04 · 10 citations

  articleOpen access

  BACKGROUND: Genetic studies implicate the oncogenic transcription factor Forkhead Box M1 (FOXM1) as a potential therapeutic target in high-grade serous ovarian cancer (HGSOC). We evaluated the activity of different FOXM1 inhibitors in HGSOC cell models. RESULTS: We treated HGSOC and fallopian tube epithelial (FTE) cells with a panel of previously reported FOXM1 inhibitors. Based on drug potency, efficacy, and selectivity, determined through cell viability assays, we focused on two compounds, NB-…

  PublisherOA PDFDOI

Frequent coauthors

• John A. Katzenellenbogen

  University of Illinois Urbana-Champaign

  78 shared

• Benita S. Katzenellenbogen

  University of Illinois Urbana-Champaign

  57 shared

• Yvonne Ziegler

  University of Illinois Urbana-Champaign

  28 shared

• Valeria Sanabria Guillen

  20 shared

• Jian Min

  Hubei University

  19 shared

• K.W. Nettles

  Scripps Research Institute

  16 shared

• Kathryn E. Carlson

  University of Illinois Urbana-Champaign

  15 shared

• Shunchao Yan

  China Medical University

  14 shared

Labs

• Kim LabPI

Awards & honors

• Searle Scholar (2020)

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