About

Samir Kelada is an Associate Professor at the University of North Carolina School of Medicine. His research focuses on understanding the complex interactions between genes and environmental factors in human health, particularly in relation to airway diseases such as asthma. His lab aims to identify and characterize gene-environment interactions that influence disease susceptibility, with a specific interest in how the airway responds to exposures like allergens or pathogens. To achieve this, he employs a systems genetics approach to study gene expression in the lung, especially airway epithelia, across many individuals to identify genetic determinants of gene expression. This work seeks to uncover master regulators of gene expression that may serve as therapeutic targets or provide insight into disease mechanisms.

Research topics

• Art history
• Philosophy
• Paleontology
• Medicine
• Biology
• Classics
• Environmental ethics
• Evolutionary biology
• History
• Library science
• Genetics

Selected publications

• Ozone‐induced changes in the murine lung extracellular vesicle small RNA landscape

  Physiological Reports · 2021 · 18 citations

  Senior authorCorresponding
  • Library science
  • Medicine
  • Environmental ethics

  -induced respiratory inflammation.

  DOI

• Inferring the Allelic Series at QTL in Multiparental Populations

  Genetics · 2020 · 17 citations

  • Biology
  • Genetics
  • Evolutionary biology

  Synthetic Population Resource (DSPR). We find that, although posterior inference of the exact allelic series is often uncertain, we are able to distinguish biallelic QTL from more complex multiallelic cases. Additionally, our allele-based approach improves haplotype effect estimation when the true number of functional alleles is small. Our method, Tree-Based Inference of Multiallelism via Bayesian Regression (TIMBR), provides new insight into the genetic architecture of QTL in MPPs.

  DOI

Recent grants

• Systems-level transcriptomic analyses to Identify mouse models of asthma

  NIH · $2.0M · 2015–2020

• Gene-Environment Interactions with Ozone in Experimental Asthma

  NIH · $2.2M · 2015–2020

Frequent coauthors

• Gregory J. Smith

  27 shared

• Kathryn M. McFadden

  University of North Carolina at Chapel Hill

  23 shared

• Francis S. Collins

  National Institutes of Health

  20 shared

• Adelaide Tovar

  University of Michigan–Ann Arbor

  20 shared

• Joseph M. Thomas

  19 shared

• Elissa J. Chesler

  Jackson Laboratory

  18 shared

• Barbara R. Grubb

  17 shared

• William Valdar

  University of North Carolina at Chapel Hill

  17 shared

Labs

• Kelada LabPI

Education

• Ph.D., Toxicology

  University of North Carolina at Chapel Hill

  2000

• M.S., Toxicology

  University of North Carolina at Chapel Hill

  1996

• B.S., Toxicology

  University of North Carolina at Chapel Hill

  1994

Similar researchers at University of North Carolina at Chapel Hill

• Barry M. Popkinh-170
• Cynthia Bulikh-134
• Doug Perkinsh-115
• Paul Watkinsh-107
• Linda Adairh-106