About

Samie Jaffrey is a professor at Weill Cornell Medicine and Cornell University in New York, NY. His laboratory focuses on uncovering the molecular basis for altered gene expression in neurodevelopmental disorders, autism, and cancer. The research aims to understand how cellular RNA regulation is affected in these diseases, which is identified as a hallmark of various pathological conditions. The lab employs a combination of molecular biology, chemical biology, imaging, and bioinformatics approaches to define the mechanisms of RNA regulation in both normal and disease states. Through this work, Jaffrey's research seeks to reveal new paradigms of gene expression and mechanisms underlying disease processes.

Research topics

• Cell biology
• Genetics
• Biology
• Computational biology

Selected publications

• Biomolecular condensates create phospholipid-enriched microenvironments

  Nature Chemical Biology · 2023 · 57 citations

  • Chemistry
  • Biochemistry
  • Biophysics
  PublisherOA PDFDOI

• Hidden codes in mRNA: Control of gene expression by m6A

  Molecular Cell · 2022 · 292 citations

  Senior authorCorresponding
  • Biology
  • Genetics
  • Cell biology
  DOI

• Caspase-11 interaction with NLRP3 potentiates the noncanonical activation of the NLRP3 inflammasome

  Nature Immunology · 2022 · 106 citations

  • Cell biology
  • Chemistry
  • Biology
  PublisherOA PDFDOI

• N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation

  Cancer Cell · 2021 · 237 citations

  • Cell biology
  • Biology
  • Chemistry
  DOI

• mTORC1 promotes cell growth via m6A-dependent mRNA degradation

  Molecular Cell · 2021 · 115 citations

  • Biology
  • Cell biology
  • Genetics
  DOI

Frequent coauthors

• Jaffrey Samie

  Institute of Structural and Molecular Biology

  4 shared

• Anke Sparmann

  Helmholtz Centre for Infection Research

  4 shared

• Shino Murakami

  Weill Cornell Medicine

  1 shared

Similar researchers at Cornell University

• Edward Bucklerh-182
• Robert Sternbergh-168
• John P. Mooreh-153
• Olivier Elementoh-150
• Andy Clarkh-142