
Edward Buckler
· Plant GeneticistCornell University · Horticulture
Active 1996–2026
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About
Edward S. Buckler is a plant geneticist with the USDA Agricultural Research Service and holds an adjunct appointment at Cornell University in the School of Integrative Plant Science's Plant Breeding and Genetics Section. His work focuses on both quantitative and statistical genetics in maize as well as other crops such as cassava. The Buckler Lab for Maize Genetics and Diversity uses functional genomic approaches to dissect complex traits in maize, biofuel grasses, and grapes. The lab utilizes the natural diversity of these plant genomes to identify the individual nucleotides responsible for complex (quantitative) variation.
Research topics
- Biology
- Genetics
- Computer Science
- Agronomy
- Artificial Intelligence
- Computational biology
- Evolutionary biology
- Botany
- Ecology
- Data science
Selected publications
Reconstructing the maize leaf regulatory network using ChIP-seq data of 104 transcription factors
Nature Communications · 2020 · 236 citations
The transcription regulatory network inside a eukaryotic cell is defined by the combinatorial actions of transcription factors (TFs). However, TF binding studies in plants are too few in number to produce a general picture of this complex network. In this study, we use large-scale ChIP-seq to reconstruct it in the maize leaf, and train machine-learning models to predict TF binding and co-localization. The resulting network covers 77% of the expressed genes, and shows a scale-free topology and fu…
Deep learning for plant genomics and crop improvement
Current Opinion in Plant Biology · 2020 · 180 citations
Senior authorCorrespondingOur era has witnessed tremendous advances in plant genomics, characterized by an explosion of high-throughput techniques to identify multi-dimensional genome-wide molecular phenotypes at low costs. More importantly, genomics is not merely acquiring molecular phenotypes, but also leveraging powerful data mining tools to predict and explain them. In recent years, deep learning has been found extremely effective in these tasks. This review highlights two prominent questions at the intersection of g…
The Plant Cell · 2020 · 130 citations
Senior authorCorresponding) Nested Association Mapping (NAM) population. The NAM population has been and continues to be an invaluable resource for the maize genetics community and has yielded insights into the genetic architecture of complex traits. The parental lines have become some of the most well-characterized maize germplasm, and their de novo assemblies were recently made publicly available. As we enter an exciting new stage in maize genomics, this retrospective will summarize the design and intentions behind the…
Comparative evolutionary genetics of deleterious load in sorghum and maize
Nature Plants · 2021 · 115 citations
G3 Genes Genomes Genetics · 2021 · 101 citations
High-dimensional and high-throughput genomic, field performance, and environmental data are becoming increasingly available to crop breeding programs, and their integration can facilitate genomic prediction within and across environments and provide insights into the genetic architecture of complex traits and the nature of genotype-by-environment interactions. To partition trait variation into additive and dominance (main effect) genetic and corresponding genetic-by-environment variances, and to…
Recent grants
Biology of Rare Alleles in Maize and Its Wild Relatives
NSF · $13.3M · 2013–2019
High Density Scoreable Markers for Maize Trait Dissection
NSF · $963k · 2006–2009
NSF · $1.7M · 2010–2014
Frequent coauthors
- 340 shared
Peter J. Bradbury
- 184 shared
M. Cinta Romay
Cornell University
- 182 shared
James B. Holland
Agricultural Research Service
- 166 shared
Michael A. Gore
Cornell University
- 162 shared
Michael D. McMullen
- 153 shared
Sherry Flint‐Garcia
United States Department of Agriculture
- 122 shared
Zhiwu Zhang
Washington State University
- 121 shared
John Doebley
University of Wisconsin–Madison
Education
- 1997
PhD, Biological Science
University of Missouri Columbia
Awards & honors
- 2025 Barbara McClintock Prize for Plant Genetics and Genome…
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