Sally A. Frautschy

About

Sally A. Frautschy is a Professor-in-Residence in the Departments of Neurology and Medicine at UCLA. Her research focuses on neurodegeneration, neuroinflammation, and the pathogenesis of Alzheimer's disease. She has contributed significantly to understanding the role of metabolic and vascular factors in tau pathology, as well as developing interventions such as curcumin and dietary modifications to mitigate neurodegenerative processes. Her work includes evaluating small-molecule disassemblers of pathological tau fibrils, investigating metabolic deficits in Alzheimer's models, and exploring neuroinflammatory mechanisms. Dr. Frautschy's research also encompasses the development of imaging techniques for amyloid pathology and the study of neurovascular interactions in dementia. Her extensive publication record and ongoing projects underscore her leadership in advancing the understanding and potential treatment strategies for neurodegenerative diseases.

Research topics

• Computer Science
• Medicine
• Chemistry
• Internal medicine
• Artificial Intelligence
• Psychology
• Ophthalmology
• Neuroscience
• Biochemistry
• Biology

Selected publications

• Sectoral segmentation of retinal amyloid imaging in subjects with cognitive decline

  Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · 2020 · 60 citations

  INTRODUCTION: Despite advances in imaging retinal amyloidosis, a quantitative and topographical investigation of retinal amyloid beta burden in patients with cognitive decline has never been reported. METHODS: We used the specific amyloid-binding fluorophore curcumin and laser ophthalmoscopy to assess retinal amyloid imaging (RAI) in 34 patients with cognitive decline. We automatically quantified retinal amyloid count (RAC) and area in the superotemporal retinal sub-regions and performed correla…

  DOI

• The Novel Omega-6 Fatty Acid Docosapentaenoic Acid Positively Modulates Brain Innate Immune Response for Resolving Neuroinflammation at Early and Late Stages of Humanized APOE-Based Alzheimer's Disease Models

  Frontiers in Immunology · 2020 · 48 citations

  . First, we found that dietary LA reduced proinflammatory cytokines of IL1-β, IL-6, as well as mRNA expression of COX2 toward resolving neuroinflammation with an increase of IL-10 in adult AD models E3FAD and E4FAD mice. Brain fatty acid assays showed a five to six-fold increase in DPAn-6 by dietary LA, especially more in E4FAD mice, when compared to standard diet. Thus, we tested DPAn-6 in aged E4FAD mice. After DPAn-6 was administered to the E4FAD mice by oral gavage for three weeks, we found…

  PublisherDOI

• Retinal Venular Tortuosity Jointly with Retinal Amyloid Burden Correlates with Verbal Memory Loss: A Pilot Study

  Cells · 2021 · 36 citations

  INTRODUCTION: Retinal imaging is a non-invasive tool to study both retinal vasculature and neurodegeneration. In this exploratory retinal curcumin-fluorescence imaging (RFI) study, we sought to determine whether retinal vascular features combined with retinal amyloid burden correlate with the neurocognitive status. METHODS: We used quantitative RFI in a cohort of patients with cognitive impairment to automatically compute retinal amyloid burden. Retinal blood vessels were segmented, and the vess…

  PublisherOA PDFDOI

• Editorial: Role of Inflammation in Neurodegenerative Diseases

  Frontiers in Immunology · 2022-06-21 · 19 citations

  editorialOpen access

  EDITORIAL article Front. Immunol., 21 June 2022Sec. Multiple Sclerosis and Neuroimmunology Volume 13 - 2022 | https://doi.org/10.3389/fimmu.2022.958487

  PublisherOA PDFDOI

• A sensitive LC-MS assay using derivatization with boron trifluoride to quantify curcuminoids in biological samples

  Analytical Biochemistry · 2020 · 9 citations

  PublisherOA PDFDOI

Recent grants

• NIH Grant RC1AG035878

  NIH · $1.0M · 2012

• NIH Grant R01NS030195

  NIH · $374k · 1997

• NIH Grant I01RX000669

  NIH · 2016

Frequent coauthors

• Greg M. Cole

  University of California, Los Angeles

  298 shared

• Fusheng Yang

  145 shared

• Bruce Teter

  123 shared

• Gregory M. Cole

  University of California, Los Angeles

  116 shared

• Qiu‐Lan Ma

  University of Southern California

  110 shared

• Oliver J. Ubeda

  Geriatric Research Education and Clinical Center

  81 shared

• Giselle P. Lim

  University of California, Los Angeles

  76 shared

• Mychica Jones

  VA Greater Los Angeles Healthcare System

  55 shared

Education

• M.D., Neurology

  University of California, Los Angeles

  1980

• B.A., Psychology

  University of California, Los Angeles

  1976

Similar researchers at University of California, Los Angeles

• David B. Reubenh-90
• Cathy Alessih-77