Gregory Cole

About

Gregory M. Cole is a Professor-in-Residence in the Department of Neurology at UCLA's David Geffen School of Medicine. His research primarily focuses on neurodegenerative diseases, particularly Alzheimer's disease, exploring mechanisms of pathology and potential therapeutic interventions. His work includes investigating tauopathy in mice and humans, surrogate plasma biomarkers for brain trauma-initiated neurodegenerative disease, and modulating innate immune function to prevent age-related neurodegeneration. Dr. Cole has contributed significantly to understanding the biochemical and molecular underpinnings of Alzheimer's, including amyloid pathology, synaptic biomarkers, and neuroinflammation. His research employs a multidisciplinary approach, integrating pharmacogenomics, multiomics analysis, and innovative imaging techniques to identify biomarkers and develop potential treatments for neurodegenerative conditions.

Research topics

• Biochemistry
• Chemistry
• Chromatography
• Psychology
• Genetics
• Medicine
• Clinical psychology
• Biology
• Bioinformatics
• Internal medicine

Selected publications

• Neuroinflammation in Alzheimer's disease

  The Lancet Neurology · 2015-03-16 · 6026 citations

  reviewOpen access
  PublisherOA PDFDOI

• Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study

  Alzheimer s Research & Therapy · 2012-10-29 · 522 citations

  articleOpen accessSenior author

  INTRODUCTION: Curcumin is a polyphenolic compound derived from the plant Curcuma Long Lin that has been demonstrated to have antioxidant and anti-inflammatory effects as well as effects on reducing beta-amyloid aggregation. It reduces pathology in transgenic models of Alzheimer's disease (AD) and is a promising candidate for treating human AD. The purpose of the current study is to generate tolerability and preliminary clinical and biomarker efficacy data on curcumin in persons with AD. METHODS:…

  PublisherOA PDFDOI

• Curcumin Suppresses Soluble Tau Dimers and Corrects Molecular Chaperone, Synaptic, and Behavioral Deficits in Aged Human Tau Transgenic Mice

  Journal of Biological Chemistry · 2012-12-23 · 207 citations

  articleOpen access

  The mechanisms underlying Tau-related synaptic and cognitive deficits and the interrelationships between Tau species, their clearance pathways, and synaptic impairments remain poorly understood. To gain insight into these mechanisms, we examined these interrelationships in aged non-mutant genomic human Tau mice, with established Tau pathology and neuron loss. We also examined how these interrelationships changed with an intervention by feeding mice either a control diet or one containing the bra…

  PublisherOA PDFDOI

• Clinical development of curcumin in neurodegenerative disease

  Expert Review of Neurotherapeutics · 2015-06-02 · 177 citations

  reviewOpen access

  Curcumin, a polyphenolic antioxidant derived from the turmeric root has undergone extensive preclinical development, showing remarkable efficacy in wound repair, cancer and inflammatory disorders. This review addresses the rationale for its use in neurodegenerative disease, particularly Alzheimer’s disease (AD). Curcumin is a pleiotropic molecule, which not only directly binds to and limits aggregation of the β-sheet conformations of amyloid characteristic of many neurodegenerative diseases but…

  PublisherOA PDFDOI

• Loss of MAP Function Leads to Hippocampal Synapse Loss and Deficits in the Morris Water Maze with Aging

  Journal of Neuroscience · 2014-05-21 · 134 citations

  articleOpen accessSenior author

  Hyperphosphorylation and accumulation of tau aggregates are prominent features in tauopathies, including Alzheimer's disease, but the impact of loss of tau function on synaptic and cognitive deficits remains poorly understood. We report that old (19-20 months; OKO) but not middle-aged (8-9 months; MKO) tau knock-out mice develop Morris Water Maze (MWM) deficits and loss of hippocampal acetylated α-tubulin and excitatory synaptic proteins. Mild motor deficits and reduction in tyrosine hydroxylase…

  PublisherOA PDFDOI

Recent grants

• NIH Grant RC1AG035878

  NIH · $1.0M · 2012

• NIH Grant R01AG011125

  NIH · $298k · 1996

• NIH Grant I01BX000542

  NIH · 2013

Frequent coauthors

• Sally A. Frautschy

  VA Greater Los Angeles Healthcare System

  298 shared

• Fusheng Yang

  143 shared

• Qiu‐Lan Ma

  University of Southern California

  97 shared

• Bruce Teter

  96 shared

• John Q. Trojanowski

  University of Pennsylvania

  84 shared

• Gabrielle Strobel

  Alzforum

  81 shared

• Donna L. McPhie

  Harvard University

  81 shared

• Sam Sisodia

  McLean Hospital

  81 shared

Education

• M.D.

  University of California, Los Angeles

• B.A.

  University of California, Los Angeles

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