Rui Hai Liu

About

Dr. Rui Hai Liu is a professor in the Department of Food Science at Cornell University. His current research focuses on bioactive compounds in natural products and their role in cancer prevention. His work emphasizes understanding the mechanisms of action of these compounds, particularly in relation to their anticancer properties and their effects on signal transduction pathways. Dr. Liu's research aims to explore the health benefits of phytochemicals found in fruits and vegetables, with a specific interest in their potential to prevent chronic diseases such as cancer. His contributions include investigating the structure-activity relationships of bioactive compounds like anthocyanin monomers and the functional properties of seafood polysaccharides, among others.

Research topics

• Chromatography
• Immunology
• Physiology
• Endocrinology
• Neuroscience
• Internal medicine
• Biochemistry
• Chemistry
• Organic chemistry
• Biology

Selected publications

• High-fiber diet mitigates maternal obesity-induced cognitive and social dysfunction in the offspring via gut-brain axis

  Cell Metabolism · 2021 · 283 citations

  DOI

• Physicochemical properties and bioactivity of whey protein isolate-inulin conjugates obtained by Maillard reaction

  International Journal of Biological Macromolecules · 2020 · 185 citations

  Senior authorCorresponding
  DOI

• Pu-erh Tea Restored Circadian Rhythm Disruption by Regulating Tryptophan Metabolism

  Journal of Agricultural and Food Chemistry · 2022-04-27 · 53 citations

  article

  Pu-erh tea is a healthy beverage rich in phytochemicals, and its effect on the risk of inducing circadian rhythm disorders (CRD) is unclear. In this study, healthy mice were given water or 0.25% (w/v) Pu-erh tea for 7 weeks, followed by a 40 day disruption of the light/dark cycle. CRD caused dysregulation of neurotransmitter secretion and clock gene oscillations, intestinal inflammation, and disruption of intestinal microbes and metabolites. Pu-erh tea boosted the indole and 5-hydroxytryptamine…

  PublisherDOI

• Ferulic Acid Mediates Metabolic Syndrome via the Regulation of Hepatic Glucose and Lipid Metabolisms and the Insulin/IGF-1 Receptor/PI3K/AKT Pathway in Palmitate-Treated HepG2 Cells

  Journal of Agricultural and Food Chemistry · 2022-11-11 · 36 citations

  articleSenior authorCorresponding

  Ferulic acid (FA) is one of the most abundant bound phenolics in whole grains, partly contributing to its preventive effects on metabolic syndrome (MetS). The study aims to investigate if FA mediates MetS through the regulation of hepatic metabolisms and the insulin receptor related pathways in the palmitate-treated HepG2 cells (MetS model). We found that FA (50, 100, and 200 μM) dramatically ameliorated the lipid accumulation in the MetS model. FA significantly decreased the activities of the g…

  PublisherDOI

• Phytochemical Profiles, Antioxidant Activity and Antiproliferative Mechanism of Rhodiola rosea L. Phenolic Extract

  Nutrients · 2022-08-31 · 25 citations

  articleOpen accessSenior authorCorresponding

  The phenolic profiles, antioxidant activity, antiproliferative property and the underlying molecular mechanisms of cell apoptosis of Rhodiola rosea free phenolic (RFE) were analyzed in this work. Overall, Rhodiola rosea rhizome phenolic extract (RE) contained Rhodiola rosea rhizome free phenolic extract (RFE) and Rhodiola rosea rhizome bound phenolic extract (RBE). Compared with RBE, RFE contained higher phenolic contents and possessed stronger antioxidant activity. High-performance liquid chrom…

  PublisherOA PDFDOI

Frequent coauthors

• Xiong Fu

  Innovation Team (China)

  100 shared

• Lijun You

  South China University of Technology

  61 shared

• Bisheng Zheng

  South China University of Technology

  57 shared

• Chun Chen

  South China Agricultural University

  50 shared

• Xinbo Guo

  South China University of Technology

  49 shared

• Arshad Mehmood Abbasi

  Abbottabad University of Science and Technology

  45 shared

• Chao Li

  Chengdu Academy of Agriculture and Forestry Sciences

  40 shared

• Qiang Huang

  29 shared

Labs

• Liu LabPI

  Research Group

Education

• Ph.D., Toxicology

  Cornell University

• M.D.

  Cornell University

• M.S., Nutrition and Food Toxicology

  Cornell University

Awards & honors

• 2018 Gilbert A. Leveille Award and Lectureship for his pione…
• 2018 The Institute of Food Technologists (IFT) 2018 Highly C…
• 2017 Highly Cited Researcher
• 2017 Clarivate Analytics and Web of Science Achievement Awar…
• 2017 Food System Network Nutrition and Health Innovation Awa…

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