Rogers, Thomas
· Assistant ProfessorUniversity of California, San Diego · Infectious Diseases
Active 1960–2026
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About
Thomas Rogers is an Assistant Adjunct Professor in the Department of Medicine at UC San Diego. His research focuses on the development and characterization of broadly neutralizing antibodies against coronaviruses, including SARS-CoV-2 and related viruses. His work involves targeted isolation of diverse human protective antibodies, understanding their mechanisms of protection, and exploring their potential as therapeutic agents. Rogers has contributed to the discovery of conserved sites on beta-coronavirus spike proteins, which confer protection against multiple strains, and has been involved in the development of antibody-based strategies to prevent and treat viral infections. His research also includes the use of advanced techniques such as microfluidics combined with electron microscopy to rapidly map antibody-viral glycoprotein complexes, and the design of vaccines and inhibitors targeting viral proteases.
Research topics
- Medicine
- Psychology
- Neuroscience
- Internal medicine
- Pathology
- Psychiatry
- Machine Learning
- Biology
- Political Science
- Computer Science
Selected publications
A trial of gantenerumab or solanezumab in dominantly inherited Alzheimer’s disease
Nature Medicine · 2021 · 362 citations
Scientific Reports · 2020 · 133 citations
Causal Structure Discovery (CSD) is the problem of identifying causal relationships from large quantities of data through computational methods. With the limited ability of traditional association-based computational methods to discover causal relationships, CSD methodologies are gaining popularity. The goal of the study was to systematically examine whether (i) CSD methods can discover the known causal relationships from observational clinical data and (ii) to offer guidance to accurately disco…
Longitudinal Sleep Patterns and Cognitive Impairment in Older Adults
JAMA Network Open · 2023-12-04 · 60 citations
articleOpen accessImportance: Sleep disturbances and clinical sleep disorders are associated with all-cause dementia and neurodegenerative conditions, but it remains unclear how longitudinal changes in sleep impact the incidence of cognitive impairment. Objective: To evaluate the association of longitudinal sleep patterns with age-related changes in cognitive function in healthy older adults. Design, Setting, and Participants: This cross-sectional study is a retrospective longitudinal analyses of the Seattle Long…
Alzheimer s Research & Therapy · 2023 · 22 citations
BACKGROUND: Exposure to repetitive head impacts (RHI) in American football players can lead to cognitive impairment and dementia due to neurodegenerative disease, particularly chronic traumatic encephalopathy (CTE). The pathognomonic lesion of CTE consists of perivascular aggregates of hyper-phosphorylated tau in neurons at the depths of cortical sulci. However, it is unclear whether exposure to RHI accelerates amyloid-β (Aβ) plaque formation and increases the risk for Alzheimer's disease (AD).…
Alzheimer s Research & Therapy · 2024-03-14 · 18 citations
articleOpen accessBACKGROUND: Functional connectivity (FC) biomarkers play a crucial role in the early diagnosis and mechanistic study of Alzheimer's disease (AD). However, the identification of effective FC biomarkers remains challenging. In this study, we introduce a novel approach, the spatiotemporal graph convolutional network (ST-GCN) combined with the gradient-based class activation mapping (Grad-CAM) model (STGC-GCAM), to effectively identify FC biomarkers for AD. METHODS: This multi-center cross-racial re…
Recent grants
NIH · $218.6M · 2012
NIH · $25.6M · 2018
Frequent coauthors
- 304 shared
Mary Sano
Icahn School of Medicine at Mount Sinai
- 244 shared
Paul Aisen
University of Southern California
- 228 shared
Clifford R. Jack
WinnMed
- 228 shared
Paul Aisen
University of Southern California
- 226 shared
Christopher H. van Dyck
Yale University
- 201 shared
Pierre N. Tariot
Banner Alzheimer’s Institute
- 197 shared
David S. Knopman
Mayo Clinic
- 195 shared
Michael Grundman
University of California, San Diego
Education
- 1983
Ph.D. (biostatistics), Biostatistics
University of Washington
- 1977
Bachelor of Arts (mathematics), Mathematics
Pomona College
- 1973
High School Diploma
Claremont High School
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