Robert S Kass

· Hosack Professor of Molecular Pharmacology and Therapeutics, Alumni Professor of Molecular Pharmacology and Therapeutics (in Neuroscience)

Columbia University · Molecular Pharmacology

Active 1961–2025

h-index87

Citations24.0k

Papers33815 last 5y

Funding$38.1M

Academic metrics are sourced from OpenAlex and public funding records; values may differ from Google Scholar.

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About

Robert S Kass is a faculty member in the Department of Molecular Pharmacology and Therapeutics at Columbia University Irving Medical Center. The page does not provide specific details about his research focus, background, or key contributions.

Research topics

Chemistry
Biology
Bioinformatics
Medicine
Internal medicine
Pharmacology
Computational biology
Cardiology
Paleontology
Genetics

Selected publications

Reengineering an Antiarrhythmic Drug Using Patient hiPSC Cardiomyocytes to Improve Therapeutic Potential and Reduce Toxicity
Cell stem cell · 2020 · 51 citations
Publisher OA PDF DOI
Regulation of IKs Potassium Current by Isoproterenol in Adult Cardiomyocytes Requires Type 9 Adenylyl Cyclase
Cells · 2019-08-27 · 24 citations
articleOpen access
The subunits KCNQ1 and KCNE1 generate the slowly activating, delayed rectifier potassium current, IKs, that responds to sympathetic stimulation and is critical for human cardiac repolarization. The A-kinase anchoring protein Yotiao facilitates macromolecular complex formation between IKs and protein kinase A (PKA) to regulate phosphorylation of KCNQ1 and IKs currents following beta-adrenergic stimulation. We have previously shown that adenylyl cyclase Type 9 (AC9) is associated with a KCNQ1-Yoti…
Publisher OA PDF DOI
Detection of Nav1.5 Conformational Change in Mammalian Cells Using the Noncanonical Amino Acid ANAP
Biophysical Journal · 2019-08-29 · 23 citations
articleOpen accessSenior author
Publisher OA PDF DOI
Potassium Channels as Therapeutic Targets in Pulmonary Arterial Hypertension
Biomolecules · 2022 · 17 citations
gene that encodes a key subunit, SUR1, of the ATP-sensitive potassium channel (KATP) were established as the first two potassium channelopathies in human cohorts with pulmonary arterial hypertension. Moreover, voltage-gated potassium channels (Kv) represent a third family of potassium channels with genetic changes observed in association with PAH. While other ion channel genes have since been reported in association with PAH, this review focuses on KCNK3, KATP, and Kv potassium channels as promi…
Publisher OA PDF DOI
Divergent regulation of KCNQ1/E1 by targeted recruitment of protein kinase A to distinct sites on the channel complex
eLife · 2023-08-31 · 12 citations
articleOpen access
The slow delayed rectifier potassium current, I Ks , conducted through pore-forming Q1 and auxiliary E1 ion channel complexes is important for human cardiac action potential repolarization. During exercise or fright, I Ks is up-regulated by protein kinase A (PKA)-mediated Q1 phosphorylation to maintain heart rhythm and optimum cardiac performance. Sympathetic up-regulation of I Ks requires recruitment of PKA holoenzyme (two regulatory – RI or RII – and two catalytic Cα subunits) to Q1 C-terminus…
Publisher DOI

Recent grants

NIH Grant R55HL021922
NIH · $100k · 1993
NIH Grant R01HL021922
NIH · $2.3M · 2003
Modulation of KCNQ1 channel activity
NIH · $2.7M · 2014–2023

Frequent coauthors

Kevin J. Sampson
Columbia University
109 shared
Colleen E. Clancy
University of California, Davis
50 shared
Vivek Iyer
Association Clinique et Thérapeutique Infantile du Val de Marne
43 shared
Connie R. Bezzina
Amsterdam University Medical Centers
38 shared
Stanley Nattel
Montreal Heart Institute
38 shared
András Varró
Hungarian Research Network
38 shared
R Abney'
University of Rochester
36 shared
Balázs Ördög
Leiden University Medical Center
36 shared

Labs

Kass LabPI

Education

Ph.D., Physics
University of Michigan
1972
M.Sc., Physics
University of Michigan
1969
B.Sc. High Distinction in Physics B.Sc., Physics
University of Illinois Urbana-Champaign University Libraries
1968

Awards & honors

Phi Eta Sigma (1967)
Phi Beta Kappa, High Distinction in Physics (1968)
Danforth Fellow (University of Michigan) (1969)
Research Career Development Award (NHLBI) (1978)
Excellence in Teaching (University of Rochester) (1982)

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