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Gary W. Miller

Gary W. Miller

· Adrienne Block Professor of Environmental Health Sciences (in Molecular Pharmacology and Therapeutics), Vice Dean for Research Strategy and Innovation, Mailman School of Public Health

Columbia University · Molecular Pharmacology

Active 1916–2026

h-index90
Citations32.0k
Papers547134 last 5y
Funding$139.2M5 active

Academic metrics are sourced from OpenAlex and public funding records; values may differ from Google Scholar.

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About

Gary W. Miller is a faculty member in the Department of Molecular Pharmacology and Therapeutics at Columbia University Irving Medical Center. The page does not provide specific details about his research focus, background, or key contributions.

Research topics

  • Computer Science
  • Pathology
  • Artificial Intelligence
  • Biology
  • Medicine
  • Data science
  • Computational biology
  • Chemistry
  • Environmental health
  • Chromatography

Selected publications

  • The exposome and health: Where chemistry meets biology

    Science · 2020 · 981 citations

    Senior authorCorresponding

    Despite extensive evidence showing that exposure to specific chemicals can lead to disease, current research approaches and regulatory policies fail to address the chemical complexity of our world. To safeguard current and future generations from the increasing number of chemicals polluting our environment, a systematic and agnostic approach is needed. The "exposome" concept strives to capture the diversity and range of exposures to synthetic chemicals, dietary constituents, psychosocial stresso…

    DOI

  • Sampling interstitial fluid from human skin using a microneedle patch

    Science Translational Medicine · 2020 · 348 citations

    Tissue interstitial fluid (ISF) surrounds cells and is an underutilized source of biomarkers that complements conventional sources such as blood and urine. However, ISF has received limited attention due largely to lack of simple collection methods. Here, we developed a minimally invasive, microneedle-based method to sample ISF from human skin that was well tolerated by participants. Using a microneedle patch to create an array of micropores in skin coupled with mild suction, we sampled ISF from…

    DOI

  • An actionable annotation scoring framework for gas chromatography-high-resolution mass spectrometry

    Exposome · 2022 · 73 citations

    Omics-based technologies have enabled comprehensive characterization of our exposure to environmental chemicals (chemical exposome) as well as assessment of the corresponding biological responses at the molecular level (eg, metabolome, lipidome, proteome, and genome). By systematically measuring personal exposures and linking these stimuli to biological perturbations, researchers can determine specific chemical exposures of concern, identify mechanisms and biomarkers of toxicity, and design inte…

    DOI

  • Integrating exposomics into biomedicine

    Science · 2025-04-24 · 51 citations

    articleOpen access1st authorCorresponding

    Assessing a full range of environmental exposures will improve human health.

    PublisherOA PDFDOI

  • Deciphering proteins in Alzheimer’s disease: A new Mendelian randomization method integrated with AlphaFold3 for 3D structure prediction

    Cell Genomics · 2024-12-01 · 23 citations

    articleOpen access

    Hidden confounding biases hinder identifying causal protein biomarkers for Alzheimer's disease in non-randomized studies. While Mendelian randomization (MR) can mitigate these biases using protein quantitative trait loci (pQTLs) as instrumental variables, some pQTLs violate core assumptions, leading to biased conclusions. To address this, we propose MR-SPI, a novel MR method that selects valid pQTL instruments using Leo Tolstoy's Anna Karenina principle and performs robust post-selection inferen…

    PublisherDOI

Recent grants

Frequent coauthors

  • Marc G. Caron

    Duke University Hospital

    96 shared

  • W. Michael Caudle

    Emory University

    79 shared

  • Raul R. Gainetdinov

    65 shared

  • Dean P. Jones

    Emory University

    55 shared

  • Vrinda Kalia

    Columbia University

    47 shared

  • Sara R. Jones

    Wake Forest University

    47 shared

  • Jason R. Richardson

    University of Georgia

    42 shared

  • Douglas I. Walker

    Emory University

    41 shared

Labs

Education

  • Postdoc, Cell Biology

    Duke University

    1998

  • Postdoc, Neurology

    Emory University

    1997

  • PhD, Physiology and Pharmacology

    University of Georgia

    1995

Awards & honors

  • Editor-in-Chief of Exposome (2021-present)
  • Editor-in-Chief of Toxicological Sciences (2013-2019)

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