Richard Kraig
· William D. Mabie ProfessorUniversity of Chicago · Neurology
Active 1966–2021
Academic metrics are sourced from OpenAlex and public funding records; values may differ from Google Scholar.
About
Dr. Richard Kraig is a professor at the University of Chicago in the Department of Neurology. His expertise encompasses migraine patient care, migraine research, and cerebrovascular disease research. He focuses on the diagnosis and treatment of migraine headaches and oversees the Cerebrovascular Disease and Aging Laboratories, which conduct research on migraine, stroke, epilepsy, and cognitive decline associated with aging. As an active researcher, Dr. Kraig investigates how physical, mental, and social activities can mitigate the impact of neurological diseases, examining mechanisms by which the brain naturally protects itself. His research aims to identify cellular and molecular targets for therapeutic strategies against brain diseases, which informs his development of individualized treatment plans for patients in the Migraine Headache Clinic. Additionally, Dr. Kraig is involved in teaching medical students, graduate students, and residents, contributing to the education of future healthcare professionals.
Research topics
- Neuroscience
- Biology
- Internal medicine
- Medicine
- Endocrinology
- Cell biology
- Anesthesia
- Pharmacology
- Molecular biology
- Immunology
Selected publications
Glia · 2013-12-04 · 233 citations
articleOpen accessSenior authorCorrespondingAlthough commonly considered a disease of white matter, gray matter demyelination is increasingly recognized as an important component of multiple sclerosis (MS) pathogenesis, particularly in the secondary progressive disease phase. Extent of damage to gray matter is strongly correlated to decline in memory and cognitive dysfunction in MS patients. Aging likewise occurs with cognitive decline from myelin loss, and age‐associated failure to remyelinate significantly contributes to MS progression.…
Cell · 2019-04-01 · 225 citations
reviewOpen accessIFNγ-stimulated dendritic cell exosomes as a potential therapeutic for remyelination
Journal of Neuroimmunology · 2013-11-09 · 184 citations
articleSenior authorCorrespondingCellular and Molecular Neurobiology · 2016-03-18 · 98 citations
articleOpen accessSenior authorJournal of Neurochemistry · 2013-04-15 · 97 citations
articleSenior authorCorrespondingAbstract Spreading depression ( SD ), the most likely cause of migraine aura and perhaps migraine, occurs with increased oxidative stress ( OS ). SD increases reactive oxygen species ( ROS ), and ROS , in turn, can signal to increase neuronal excitability, which includes increased SD susceptibility. SD also elevates tumor necrosis factor‐α ( TNF ‐α), which increases neuronal excitability. Accordingly, we probed for the cellular origin of OS from SD and its relationship to TNF ‐α, which might pro…
Recent grants
NIH · $27.3M · 2017
Environment Enrichment, Neuroprotection and Spreading Depression
NIH · $7.5M · 1983–2022
NIH · $568k · 2015
Frequent coauthors
- 22 shared
Phillip E. Kunkler
Indiana University School of Medicine
- 14 shared
Fred Plum
- 14 shared
William A. Pulsinelli
- 13 shared
Raymond E. Hulse
Janelia Research Campus
- 13 shared
David M. White
American Association of Kidney Patients
- 13 shared
Aya D. Pusic
University of Chicago
- 10 shared
Charles Nicholson
University of Birmingham
- 9 shared
Wade G. Swenson
Molecular Oncology (United States)
Labs
Cerebrovascular Disease and Aging LaboratoriesPI
Education
M.D.
University of Chicago
B.A.
University of California, Berkeley
Similar researchers at University of Chicago
- Resume-aware match score
- Save to shortlist
- AI-drafted outreach
See your match with Richard Kraig
PhdFit ranks faculty by your research interests, methods, and publications — grounded in their actual work, not templates.
- Free to start
- No credit card
- 30-second signup