Rex Gaskins

Another renaissance for bile acid gastrointestinal microbiology

Nature Reviews Gastroenterology & Hepatology · 2024-02-21 · 149 citations

Diversity and distribution of sulfur metabolic genes in the human gut microbiome and their association with colorectal cancer

Microbiome · 2022-04-19 · 118 citations

Abstract Background Recent evidence implicates microbial sulfidogenesis as a potential trigger of colorectal cancer (CRC), highlighting the need for comprehensive knowledge of sulfur metabolism within the human gut. Microbial sulfidogenesis produces genotoxic hydrogen sulfide (H 2 S) in the human colon using inorganic (sulfate) and organic (taurine/cysteine/methionine) substrates; however, the majority of studies have focused on sulfate reduction using dissimilatory sulfite reductases (Dsr). Res…

Completion of the gut microbial epi-bile acid pathway

Gut Microbes · 2021-01-01 · 107 citations

DSM 13279. A Hidden Markov Model search against human gut metagenomes located putative 12β-HSDH genes in about 30% of subjects within the cohorts analyzed, indicating this gene is relevant in the human gut microbiome.

An expanded metabolic pathway for androgen production by commensal bacteria

Nature Microbiology · 2025-04-21 · 30 citations

CHCHD2 mediates glioblastoma cell proliferation, mitochondrial metabolism, hypoxia‑induced invasion and therapeutic resistance

International Journal of Oncology · 2023-08-25 · 19 citations

Glioblastoma (GBM) is the most common and malignant primary brain tumor affecting adults and remains incurable. The mitochondrial coiled‑coil‑helix‑coiled‑coil‑helix domain‑containing protein 2 (CHCHD2) has been demonstrated to mediate mitochondrial respiration, nuclear gene expression and cell migration; however, evidence of this in GBM is lacking. In the present study, it was hypothesized that CHCHD2 may play a functional role in U87 GBM cells expressing the constitutively active epidermal gro…