Juan J. Loor

Cyanidin‐3‐<i>O</i>‐glucoside improves non‐alcoholic fatty liver disease by promoting PINK1‐mediated mitophagy in mice

British Journal of Pharmacology · 2020 · 137 citations

BACKGROUND AND PURPOSE: Identifying safe and effective compounds that target to mitophagy to eliminate impaired mitochondria may be an attractive therapeutic strategy for non-alcoholic fatty liver disease. Here, we investigated the effects of cyanidin-3-O-glucoside (C3G) on non-alcoholic fatty liver disease (NAFLD) and the underlying mechanism. EXPERIMENTAL APPROACH: Non-alcoholic fatty liver disease was induced by a high-fat diet for 16 weeks. C3G was administered during the last 4 weeks. In vi…

Potential of Mulberry Leaf Biomass and Its Flavonoids to Improve Production and Health in Ruminants: Mechanistic Insights and Prospects

Animals · 2020 · 99 citations

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Amino acids and the regulation of oxidative stress and immune function in dairy cattle

Journal of Animal Science · 2020 · 98 citations

Extracellular vesicles in dairy cattle: research progress and prospects for practical applications

Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · 2025-08-03 · 4 citations

Intensive dairying has diminished infectious disease resistance in dairy cattle and increased the risk of disorders affecting milk quality and productive life. Development of novel health monitoring technologies, optimization of disease treatment protocols using novel biomarkers, and development of antibiotic substitutes are necessary to further enhance the productivity of dairy cattle. Extracellular vesicles (EVs) are key mediators of cellular communication and are essential for maintaining int…

The hepatic expression status of hepatocyte nuclear factor 4α in subclinical and clinical ketotic dairy cows and its impact on lipid metabolism in hepatocytes

Journal of Dairy Science · 2025-07-18 · 2 citations

Due to sustained lipolysis, excessive nonesterified fatty acid (NEFA) concentrations are a common pathological factor of ketosis in peripartal cows. The NEFA provide an energy source to the liver during the transition period, but when in excess they can induce hepatic steatosis and liver dysfunction. In nonruminants, hepatocyte nuclear factor 4α (HNF4α) is involved in lipid metabolism processes in the liver. However, it is unclear whether HNF4α regulates hepatic lipid metabolism and function in…