Qin Chen
· Professor, Pharmacogenomics, Director, Pharmacogenomics, Holsclaw Endowed Professorship, PharmacogenomicsUniversity of Arizona · Toxicology
Active 1998–2024
About
Qin Chen is a Professor specializing in Pharmacogenomics and serves as the Director of the Pharmacogenomics Holsclaw Endowed Professorship at the University of Arizona. Her leadership roles include directing the NIEHS training program at the University of Arizona for 12 years, during which she expanded trainee positions, established an External Advisory Board, supported student development, and fostered leadership training. Dr. Chen's laboratory focuses on studying the molecular biology of oxidative stress, utilizing genomic and proteomic technology to address fundamental scientific questions. Her ongoing research projects include investigating stress-induced de novo protein synthesis for organ protection, the role of Nrf2 transcription factor in cardiac injury protection, the function of Glucocorticoid Induced Leucine Zipper in the myocardium, pharmacological agents that protect the heart from ischemic and chemotherapeutic injuries, and biomarker discovery for predicting tissue injury due to oxidative stress. With extensive experience in cell biology, molecular biology, and animal models of oxidative stress, she has trained numerous postdoctoral fellows and students, contributing significantly to the field of pharmacogenomics and oxidative stress research.
Research topics
- Medicine
- Internal medicine
- Biology
- Biochemistry
- Genetics
- Neuroscience
- Endocrinology
- Chemistry
- Pharmacology
- Psychology
- Cell biology
Selected publications
Physiological Genomics · 2022 · 42 citations
Senior authorCorresponding- Biology
- Internal medicine
- Endocrinology
. Detoxification enzymes, GCLM and EPHX1, also showed decreased expression, whereas the CYP1B1 transcript was elevated in both DCM and ICM. The genes encoding metal-binding protein ferritin were decreased, whereas five out of 12 metallothionein genes showed elevated expression. Our finding on Nrf2 gene expression has been validated by meta-analysis of seven independent data sets of microarray or RNA-Seq for differential gene expression in DCM and ICM from NF controls. In conclusion, minor elevation of Nrf2 gene expression is not coupled to increases in antioxidant and detoxification genes, supporting an impairment of Nrf2 signaling in patients with heart failure. Decreases in multiple antioxidant and detoxification genes are consistent with the observed increases of oxidative stress in failing hearts.
Nrf2 for cardiac protection: pharmacological options against oxidative stress
Trends in Pharmacological Sciences · 2021 · 146 citations
1st authorCorresponding- Medicine
- Pharmacology
- Psychology
Nrf2 for protection against oxidant generation and mitochondrial damage in cardiac injury
Free Radical Biology and Medicine · 2021 · 250 citations
1st authorCorresponding- Cell biology
- Biology
- Chemistry
Recent grants
NIH · $1.2M · 2006
Mechanism and Function of Stress Induced Protein Translation
NIH · $1.4M · 2018–2023
NIH · $1.5M · 2010
Nrf2 Protein Translation for Protection Against Tissue Injury
NIH · $1.7M · 2018–2023
NIH · $414k · 2012
Frequent coauthors
- 13 shared
Haipeng Sun
Tianjin Medical University
- 11 shared
Joshua Strom
University of Arizona
- 10 shared
Beibei Xu
- 9 shared
Joseph S. Alpert
University of Arizona
- 9 shared
Victoria C. Tu
University of Arizona
- 7 shared
Olivier Toussaint
University of Namur
- 7 shared
Tarrah Dilley
- 7 shared
Jack Zhang
Awards & honors
- Distinguished Chinese Toxicology Scholar Society of Toxicolo…
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