Jeremy Garcia

About

Jeremy Garcia, of Hopi/Tewa descent and belonging to the Hospoawungwa (Roadrunner) clan, is an Associate Professor of Indigenous Education in the Department of Teaching, Learning, and Sociocultural Studies at the University of Arizona's College of Education. His research focuses on decolonization, critical Indigenous curriculum and pedagogy, Indigenous teacher education, and critical and culturally sustaining family and community engagement. He supports Indigenous educators by developing curriculum grounded in Indigenous knowledge and values, including work with the Hopi Kuuyi (Water) Curriculum and the Hopi Natwani (traditional farming) curriculum in Arizona. Currently, he collaborates with Hopi educators and the Hopi Cultural Preservations Office to create curriculum related to the history and trauma of the Moquis and Kastiilam peoples. Garcia is also a co-founding Director of the Indigenous Teacher Education Program (ITEP) at the University of Arizona. His recent publication includes a co-edited book titled 'Indigenizing Education: Transformative Research, Theories, and Praxis' (2022). Prior to his current role, he served as an Assistant Professor at the University of Wisconsin-Milwaukee and held a vital role in developing the first Native American Educational and Cultural Center at Purdue University. His background includes experience as an elementary school teacher and parent engagement coordinator on the Salt River Pima-Maricopa Indian Reservation in Arizona. He holds…

Research topics

• Medicine
• Internal medicine
• Biology
• Immunology
• Cancer research
• Oncology
• Endocrinology
• Genetics
• Pathology
• Cell biology

Selected publications

• NRF2 controls iron homeostasis and ferroptosis through HERC2 and VAMP8

  Science Advances · 2023 · 446 citations

  results in apoferritin accumulation in the autophagosome, an elevated LIP, and enhanced sensitivity to ferroptosis. Concordantly, NRF2 levels correlate with HERC2 and VAMP8 in human ovarian cancer tissues, as well as ferroptosis resistance in a panel of ovarian cancer cell lines. Last, the feasibility of inhibiting NRF2 to increase the LIP and kill cancer cells via ferroptosis was demonstrated in preclinical models, signifying the impact of NRF2 inhibition in cancer treatment.

  DOI

• Targeting NOX4 alleviates sepsis-induced acute lung injury via attenuation of redox-sensitive activation of CaMKII/ERK1/2/MLCK and endothelial cell barrier dysfunction

  Redox Biology · 2020-07-13 · 251 citations

  articleOpen access

  Increased pulmonary vascular permeability due to endothelial cell (EC) barrier dysfunction is a major pathological feature of acute respiratory distress syndrome/acute lung injury (ARDS/ALI), which is a devastating critical illness with high incidence and excessive mortality. Activation of NADPH oxidase (NOX) induces EC dysfunction via production of reactive oxygen species (ROS). However, the role(s) of NOX isoform(s), and their downstream signaling events, in the development of ARDS/ALI have re…

  PublisherDOI

• Endothelial eNAMPT amplifies pre-clinical acute lung injury: efficacy of an eNAMPT-neutralising monoclonal antibody

  European Respiratory Journal · 2020 · 82 citations

  Senior authorCorresponding

  RATIONALE: The severe acute respiratory syndrome coronavirus 2/coronavirus disease 2019 pandemic has highlighted the serious unmet need for effective therapies that reduce acute respiratory distress syndrome (ARDS) mortality. We explored whether extracellular nicotinamide phosphoribosyltransferase (eNAMPT), a ligand for Toll-like receptor (TLR)4 and a master regulator of innate immunity and inflammation, is a potential ARDS therapeutic target. METHODS: . RESULTS: mice confirmed a highly signific…

  DOI

• Differential transcriptomics in sarcoidosis lung and lymph node granulomas with comparisons to pathogen-specific granulomas

  Respiratory Research · 2020 · 25 citations

  Senior authorCorresponding

  RATIONALE: Despite the availability of multi-"omics" strategies, insights into the etiology and pathogenesis of sarcoidosis have been elusive. This is partly due to the lack of reliable preclinical models and a paucity of validated biomarkers. As granulomas are a key feature of sarcoidosis, we speculate that direct genomic interrogation of sarcoid tissues, may lead to identification of dysregulated gene pathways or biomarker signatures. OBJECTIVE: To facilitate the development sarcoidosis genomi…

  DOI

• Dysregulated Tricarboxylic Acid Cycle Metabolism Is Associated With Right Ventricular Maladaptation in Pulmonary Vascular Disease

  Journal of the American Heart Association · 2025-05-22 · 7 citations

  articleOpen access

  BACKGROUND: Right ventricular (RV) maladaptation to elevated pulmonary afterload is the primary determinant of outcomes in pulmonary artery (PA) hypertension; however, the pathobiological mechanisms underlying RV decompensation remain poorly understood. METHODS: We performed global untargeted metabolomics on plasma from 55 patients who underwent gold-standard RV-PA coupling measurements using multibeat pressure volume loop assessment in a single-center cohort and from 1027 patients with coupling…

  PublisherDOI

Recent grants

• NIH Grant R01HL069340

  NIH · $368k · 2002

• NIH Grant U01HL112696

  NIH · $470k · 2016

• NIH Grant R41HL140741

  NIH · $225k · 2020

Frequent coauthors

• Roberto F. Machado

  Indiana University – Purdue University Indianapolis

  319 shared

• Viswanathan Natarajan

  University of Illinois Chicago

  255 shared

• Sara M. Camp

  University of Florida

  249 shared

• Jason X.‐J. Yuan

  University of California System

  207 shared

• Alexander D. Verin

  Augusta University Health

  198 shared

• Steven M. Dudek

  University of Illinois Chicago

  192 shared

• Haiyang Tang

  University of Arizona

  192 shared

• Taimur Abbasi

  Massachusetts General Hospital

  189 shared

Education

• MD

  University of Texas Southwestern Medical Center

  1980

• BS

  University of Dallas

  1976

Similar researchers at University of Arizona

• Jermaine Williamsh-35
• Leona Davish-29
• Rao Xiongh-29