Peter Mancuso

About

Peter Mancuso, PhD, MS, is an Associate Professor in the Department of Nutritional Sciences at the University of Michigan School of Public Health. His research focuses on understanding how obesity and diabetes impact pulmonary infections and systemic inflammation in chronic disease. Dr. Mancuso investigates why individuals with obesity and diabetes experience greater severity of illness from respiratory tract infections, including insights gained during the COVID-19 pandemic and the 2009 Influenza A pandemic. His work involves studying lung macrophages, leukocytes, and serum from rodents and humans to characterize intracellular signaling events, inflammatory mediator synthesis, glucose transport, and bactericidal function. Dr. Mancuso's research also examines the role of leptin and other adipokines in host defense functions in pulmonary immune cells, as well as their association with chronic disease outcomes in Midlife women. His projects include exploring the impact of diet-induced obesity on immune cell function, the influence of leptin receptor polymorphisms on neutrophil recruitment and bacterial pneumonia defense, and adipokines as biomarkers for chronic disease risk. His collaborative work with epidemiologists aims to elucidate the connections between adipokines and health outcomes, contributing to potential therapeutic strategies to improve health in populations affected by obesity and diabetes.

Research topics

• Medicine
• Internal medicine
• Biochemistry
• Immunology
• Chemistry
• Biology
• Microbiology
• Endocrinology

Selected publications

• The role of adipokines in chronic inflammation

  ImmunoTargets and Therapy · 2016-05-01 · 364 citations

  reviewOpen access1st authorCorresponding

  Adipose tissue has traditionally been defined as connective tissue that stores excess calories in the form of triacylglycerol. However, the physiologic functions attributed to adipose tissue are expanding, and it is now well established that adipose tissue is an endocrine gland. Among the endocrine factors elaborated by adipose tissue are the adipokines; hormones, similar in structure to cytokines, produced by adipose tissue in response to changes in adipocyte triacylglycerol storage and local a…

  PublisherOA PDFDOI

• The Impact of Aging on Adipose Function and Adipokine Synthesis

  Frontiers in Endocrinology · 2019-03-11 · 318 citations

  reviewOpen access1st authorCorresponding

  During the last 40 years, there has been a world-wide increase in both the prevalence of obesity and an increase in the number of persons over the age of 60 due to a decline in deaths from infectious disease and the nutrition transition in low and middle income nations. While the increase in the elderly population indicates improvements in global public health, this population may experience a diminished quality of life due to the negative impacts of obesity on age-associated inflammation. Aging…

  PublisherOA PDFDOI

• IL-36γ is a crucial proximal component of protective type-1-mediated lung mucosal immunity in Gram-positive and -negative bacterial pneumonia

  Mucosal Immunology · 2017-02-08 · 73 citations

  articleOpen access
  PublisherOA PDFDOI

• Ablation of the leptin receptor in myeloid cells impairs pulmonary clearance of<i>Streptococcus pneumoniae</i>and alveolar macrophage bactericidal function

  American Journal of Physiology-Lung Cellular and Molecular Physiology · 2018-03-22 · 62 citations

  articleOpen access1st authorCorresponding

  Leptin is a pleiotropic hormone produced by white adipose tissue that regulates appetite and many physiological functions, including the immune response to infection. Genetic leptin deficiency in humans and mice impairs host defenses against respiratory tract infections. Since leptin deficiency is associated with obesity and other metabolic abnormalities, we generated mice that lack the leptin receptor (LepRb) in cells of the myeloid linage (LysM-LepRb-KO) to evaluate its impact in lean metaboli…

  PublisherOA PDFDOI

• Ozone Exposure, Cardiopulmonary Health, and Obesity: A Substantive Review

  Chemical Research in Toxicology · 2017-06-02 · 41 citations

  reviewOpen accessSenior author

  From 1999-2014, obesity prevalence increased among adults and youth. Obese individuals may be uniquely susceptible to the proinflammatory effects of ozone because obese humans and animals have been shown to experience a greater decline in lung function than normal-weight subjects. Obesity is independently associated with limitations in lung mechanics with increased ozone dose. However, few epidemiologic studies have examined the interaction between excess weight and ozone exposure among adults.…

  PublisherOA PDFDOI

Recent grants

• NIH Grant R01HL077417

  NIH · $1.8M · 2011

Frequent coauthors

• Marc Peters‐Golden

  36 shared

• MaryFran Sowers

  University of Michigan–Ann Arbor

  30 shared

• Rachel P. Wildman

  Princess Margaret Cancer Centre

  30 shared

• Sylvia Wassertheil‐Smoller

  Albert Einstein College of Medicine

  25 shared

• Matthew Allison

  University of California, San Diego

  25 shared

• Alison E. Baird

  25 shared

• Alexandra D. Ogorodnikova

  Albert Einstein College of Medicine

  25 shared

• Beatriz L. Rodríguez

  25 shared

Education

• Postdoctoral Research Fellowship Training in Pulmonary and Critical Care Medicine, Internal Medicine

  University of Michigan Health System

  1999

• B.S., Food Science

  Purdue University

  1985

Similar researchers at University of Michigan

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• Ana Baylinh-56
• Kendrin Sonnevilleh-44