Patrick S. Doyle

About

Patrick S. Doyle is the Robert T Haslam (1911) Professor in Chemical Engineering at MIT. His research focuses on chemical engineering, with particular emphasis on areas such as energy, environment and sustainability, and materials. As a faculty member, he contributes to the department's academic and research missions, engaging in innovative work that advances the field of chemical engineering.

Research topics

• Computer Science
• Nanotechnology
• Materials science
• Physics
• Mechanics
• Engineering
• Chromatography
• Process engineering
• Biology
• Chemistry

Selected publications

• Embedded droplet printing in yield-stress fluids

  Proceedings of the National Academy of Sciences · 2020 · 86 citations

  Senior authorCorresponding

  Microfluidic tools and techniques for manipulating fluid droplets have become core to many scientific and technological fields. Despite the plethora of existing approaches to fluidic manipulation, non-Newtonian fluid phenomena are rarely taken advantage of. Here we introduce embedded droplet printing-a system and methods for the generation, trapping, and processing of fluid droplets within yield-stress fluids, materials that exhibit extreme shear thinning. This technique allows for the manipulat…

  DOI

• Hydrogel-Based Colorimetric Assay for Multiplexed MicroRNA Detection in a Microfluidic Device

  Analytical Chemistry · 2020 · 80 citations

  Senior authorCorresponding

  Although microRNA (miRNA) expression levels provide important information regarding disease states owing to their unique dysregulation patterns in tissues, translation of miRNA diagnostics into point-of-care (POC) settings has been limited by practical challenges. Here, we developed a hydrogel-based microfluidic platform for colorimetric profiling of miRNAs, without the use of complex external equipment for fluidics and imaging. For sensitive and reliable measurement without the risk of sequence…

  DOI

• Data-driven organic solubility prediction at the limit of aleatoric uncertainty

  Nature Communications · 2025-08-19 · 18 citations

  articleOpen access

  Abstract Small molecule solubility is a critically important property which affects the efficiency, environmental impact, and phase behavior of synthetic processes. Experimental determination of solubility is a time- and resource-intensive process and existing methods for in silico estimation of solubility are limited by their generality, speed, and accuracy. This work presents two models derived from the FASTPROP and CHEMPROP architectures and trained on BigSolDB which are capable of predicting…

  PublisherOA PDFDOI

• Engineering considerations for next-generation oligonucleotide therapeutics

  Nature Chemical Engineering · 2024-12-23 · 13 citations

  articleOpen access
  PublisherOA PDFDOI

• Surfactant–Polymer Complexation and Competition on Drug Nanocrystal Surfaces Control Crystallinity

  ACS Applied Materials & Interfaces · 2024-06-18 · 10 citations

  articleSenior authorCorresponding

  Nanosizing drug crystals has emerged as a successful approach to enabling oral bioavailability, as increasing drug crystal surface area improves dissolution kinetics and effective solubility. Recently, bottom-up methods have been developed to directly assemble nanosized crystals by leveraging polymer and surfactant excipients during crystallization to control crystal size, morphology, and structure. However, while significant research has investigated how polymers and other single additives inhi…

  PublisherDOI

Recent grants

• Polymer Dynamics of Knotted DNA

  NSF · $300k · 2016–2019

• DNA Polymer Dynamics in Nanoconfinement

  NSF · $300k · 2009–2013

• NIH Grant R21EB008814

  NIH · $423k · 2012

Frequent coauthors

• Johan R. C. van der Maarel

  National University of Singapore

  61 shared

• Liang Dai

  China XD Group (China)

  52 shared

• T. Alan Hatton

  Massachusetts Institute of Technology

  45 shared

• Saif A. Khan

  University of Ha'il

  42 shared

• Staffan Kjelleberg

  Singapore Centre for Environmental Life Sciences Engineering

  41 shared

• Stuart A. Rice

  Agriculture and Food

  41 shared

• Mehmet Toner

  Harvard University

  41 shared

• Ki Wan Bong

  Korea University

  40 shared

Labs

• MIT ChemEPI

Education

• Ph.D., Chemical Engineering

  Massachusetts Institute of Technology

  1990

• M.S., Chemical Engineering

  Massachusetts Institute of Technology

  1986

• B.S., Chemical Engineering

  University of California, Berkeley

  1984

Awards & honors

• AIChE's Alpha Chi Sigma Award for Chemical Engineering Resea…
• Singapore Research Professorship (2021)
• J-WAFS Seed Grant (2019)
• Singapore Research Professorship (2016)
• Michael Mohr Outstanding Faculty Award (2013 & 2014)

Similar researchers at Massachusetts Institute of Technology

• Paula T. Hammondh-132
• Klavs F. Jensenh-131
• Martin Z. Bazanth-114