Paula T. Hammond
· Institute ProfessorMassachusetts Institute of Technology · Chemical Engineering
Active 1971–2026
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About
Paula T. Hammond is an Institute Professor and Dean of the School of Engineering at MIT. She holds the title of Institute Professor and is recognized for her leadership in the field of chemical engineering. Her research focuses on areas related to chemical engineering, including biomedical and biotechnology, catalysis and reaction engineering, energy, environment and sustainability, materials, math and computational systems, and transport and thermodynamics. Hammond's work contributes significantly to advancing knowledge and innovation in these areas, and she is a prominent figure within the MIT Department of Chemical Engineering.
Research topics
- Chemistry
- Computer Science
- Materials science
- Biology
- Nanotechnology
- Biomedical engineering
- Medicine
- Cell biology
- Computational biology
- Genetics
Selected publications
Plasticity of ether lipids promotes ferroptosis susceptibility and evasion
Nature · 2020 · 806 citations
Layer-by-Layer Biomaterials for Drug Delivery
Annual Review of Biomedical Engineering · 2020 · 204 citations
Controlled drug delivery formulations have revolutionized treatments for a range of health conditions. Over decades of innovation, layer-by-layer (LbL) self-assembly has emerged as one of the most versatile fabrication methods used to develop multifunctional controlled drug release coatings. The numerous advantages of LbL include its ability to incorporate and preserve biological activity of therapeutic agents; coat multiple substrates of all scales (e.g., nanoparticles to implants); and exhibit…
Massively parallel pooled screening reveals genomic determinants of nanoparticle delivery
Science · 2022 · 191 citations
Senior authorCorresponding, which inversely predicts lipid-based nanoparticle uptake in vitro and in vivo. Our work establishes the power of integrated screens for nanoparticle delivery and enables the identification and utilization of biomarkers to rationally design nanoformulations.
Advancing engineering design strategies for targeted cancer nanomedicine
Nature reviews. Cancer · 2025-08-01 · 49 citations
reviewSenior authorHigh‐Throughput Microfluidic‐Mediated Assembly of Layer‐By‐Layer Nanoparticles
Advanced Functional Materials · 2025-04-03 · 15 citations
articleOpen accessSenior authorCorrespondingSurface modification of nanoparticles (NPs) via the layer-by-layer (LbL) technique is a promising approach to generate targeted drug delivery vehicles. LbL-NPs have been successfully used in preclinical models for controlled drug release, tumor and immune cell targeting, improved pharmacokinetics and biodistribution, and controlling cellular trafficking and uptake mechanisms. A simple and scalable synthesis method for LbL-NPs that can be adapted for clinical translation is of great interest. Her…
Recent grants
NSF · $460k · 2007–2011
NIH · $745k · 2011
Integrated Genomics and Bioinformatics
NIH · $37.6M · 1997–2027
Frequent coauthors
- 162 shared
Darrell J. Irvine
Scripps Research Institute
- 92 shared
Erik C. Dreaden
Winship Cancer Institute
- 88 shared
Stephen W. Morton
- 83 shared
Kevin E. Shopsowitz
Vancouver General Hospital
- 83 shared
Stephen Lillie
- 77 shared
Joelle P. Straehla
- 67 shared
Angela M. Belcher
Massachusetts Institute of Technology
- 58 shared
Michael B. Yaffe
Massachusetts Institute of Technology
Labs
Education
- 1992
Ph.D., Chemical Engineering
Massachusetts Institute of Technology
- 1988
M.S., Chemical Engineering
Massachusetts Institute of Technology
- 1986
B.S., Chemical Engineering
University of California, Berkeley
Awards & honors
- John M. Prausnitz AIChE Institute Lecturer, 2026
- National Medal of Technology and Innovation, 2024
- Othmer Gold Medal, 2024
- Benjamin Franklin Medal in Chemistry, 2024
- James R. Killian Jr. Faculty Achievement Award, 2023-24
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