Muhammad Zaman

About

Muhammad Zaman is a Professor of Biomedical Engineering at Boston University and the principal investigator of the Laboratory for Molecular & Cellular Dynamics. He holds a PhD in chemistry from the University of Chicago and was a Hermann and Margaret Sokol Foundation Fellow post-doctoral fellow in cancer research at the Massachusetts Institute of Technology. His research focuses on two main areas: global health and cancer. In global health, his interests include improving health systems through understanding disease determinants, developing better diagnostics, and helping local stakeholders implement evidence-based policies. His current work addresses antimicrobial resistance, OneHealth integrated solutions, drug quality testing, and diagnostics for maternal health, with a focus on access to better health for refugees and marginalized populations. His lab collaborates closely with field and policy work to ensure effective implementation, and involves students from diverse disciplines to address global health challenges. The second area of research involves fundamental questions in tumor metastasis, including cell migration and cell-matrix interactions, utilizing experimental and computational strategies rooted in cell biology, chemistry, mechanics, and imaging to understand cell responses in 3D environments. His work aims to develop multi-scale models to quantify cell signaling, adhesion, and motion, contributing to the understanding of cancer progression.

Research topics

• Political Science
• Chemistry
• Biology
• Ecology
• Law
• Intensive care medicine
• Materials science
• Environmental health
• Business
• Medicine

Selected publications

• COVID-19 and risks to the supply and quality of tests, drugs, and vaccines

  The Lancet Global Health · 2020 · 165 citations

  Senior authorCorresponding

  Emergency efforts are underway to find optimum medical products to prevent infection and diagnose and treat patients during the coronavirus disease 2019 (COVID-19) pandemic. Production and supply chains for COVID-19 candidate drugs (such as chloroquine and hydroxychloroquine), and for many other essential medical products, are being impaired by this crisis.1Guerin PJ Singh-Phulgenda S Strub-Wourgaft N The consequence of COVID-19 on the global supply of medical products: why Indian generics matte…

  DOI

• Heavy Metal Toxicity in Armed Conflicts Potentiates AMR in A. baumannii by Selecting for Antibiotic and Heavy Metal Co-resistance Mechanisms

  Frontiers in Microbiology · 2020 · 155 citations

  in war zones.

  PublisherOA PDFDOI

• A novel jamming phase diagram links tumor invasion to non-equilibrium phase separation

  iScience · 2021 · 94 citations

  It is well established that the early malignant tumor invades surrounding extracellular matrix (ECM) in a manner that depends upon material properties of constituent cells, surrounding ECM, and their interactions. Recent studies have established the capacity of the invading tumor spheroids to evolve into coexistent solid-like, fluid-like, and gas-like phases. Using breast cancer cell lines invading into engineered ECM, here we show that the spheroid interior develops spatial and temporal heterog…

  DOI

Recent grants

• Characterizing cell morphology, adhesion, and migration in 2.5 and 3D cell-derived extracellular matrices

  NSF · $420k · 2012–2017

• NIH Grant U01CA177799

  NIH · $3.0M · 2019

• NIH Grant R01CA132633

  NIH · $1.5M · 2013

Frequent coauthors

• Fabian Spill

  University of Birmingham

  42 shared

• Michael Mak

  Yale University

  31 shared

• Roger D. Kamm

  Massachusetts Institute of Technology

  26 shared

• Thomas Franz

  University of Cape Town

  16 shared

• Jacopo Ferruzzi

  16 shared

• Sharon Wei Ling Lee

  Massachusetts Institute of Technology

  16 shared

• James P. Butler

  Harvard University

  16 shared

• Paul N. Newton

  13 shared

Education

• Ph.D.

  University of Chicago

Awards & honors

• FEBS Outstanding Young Investigator Award
• Regents Teaching Award

Similar researchers at Boston University

• Melissa Holth-35
• Samuel Cookh-7
• Anna Henchmanh-5