Mohammad Fallahi-Sichani
· Associate Professor of Biomedical EngineeringUniversity of Virginia · Molecular Physiology and Biological Physics
Active 2004–2024
About
Professor Mohammad Fallahi-Sichani is the head of the Fallahi-Sichani Lab at the University of Virginia, within the Department of Biomedical Engineering. His laboratory focuses on systems biology research aimed at understanding the mechanisms through which human cells respond heterogeneously to environmental and therapeutic perturbations. This includes studying changes in gene expression, metabolic states, and cell fate decisions such as differentiation, cell division, growth arrest, or induction of cell death in response to treatments like cancer drugs. His research addresses the challenge of deciphering how biomolecules within cells, embedded in complex multi-component networks, govern cellular responses and plasticity, which vary among different cell types and even among genetically identical cells under the same conditions. The lab employs a transdisciplinary approach that combines experimental, analytical, and computational tools to assay cellular networks, analyze high-dimensional datasets, and develop quantitative models of cellular responses. This iterative methodology has led to the discovery of novel mechanisms of cellular signaling, plasticity, and heterogeneity, which are validated and utilized to inform the development of improved therapies for precision medicine.
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