Michael J. Clark

About

Michael J. Clark is an Assistant Professor of Practice at the University of Arizona, affiliated with the School of Nutritional Sciences and Wellness. He is based on the Yuma Campus and holds the credentials SNS, BS, and MPA. His role involves teaching and practice within the field of nutritional sciences, contributing to the university's educational mission in this area. His contact information includes an email address (mjclark2@arizona.edu) and a phone number (520-621-1186), with office hours from 9AM to 3PM, Monday through Friday. The university recognizes his position as part of its broader efforts in education, community service, and engagement with Indigenous communities.

Research topics

• Biology
• Botany
• Genetics
• Microbiology
• Chemistry

Selected publications

• Localized recombination drives diversification of killing spectra for phage-derived syringacins

  The ISME Journal · 2018-08-31 · 33 citations

  articleOpen access

  To better understand the potential for antagonistic interactions between members of the same bacterial species, we have surveyed bacteriocin killing activity across a diverse suite of strains of the phytopathogen Pseudomonas syringae. Our data demonstrate that killing activity from phage-derived bacteriocins of P. syringae (R-type syringacins) is widespread. Despite a high overall diversity of bacteriocin activity, strains can broadly be classified into five main killing types and two main sensi…

  PublisherOA PDFDOI

• Transcriptional Profiles of a Foliar Fungal Endophyte ( <i>Pestalotiopsis</i> , Ascomycota) and Its Bacterial Symbiont ( <i>Luteibacter</i> , <i>Gammaproteobacteria</i> ) Reveal Sulfur Exchange and Growth Regulation during Early Phases of Symbiotic Interaction

  mSystems · 2022 · 25 citations

  .

  PublisherDOI

• Interspecies killing activity of Pseudomonas syringae tailocins

  Microbiology · 2022 · 22 citations

  tailocins and establish a platform for further investigations into the evolution of tailocin host range and strain specificity.

  PublisherDOI

• Identifying transposon insertions in bacterial genomes through nanopore sequencing

  bioRxiv (Cold Spring Harbor Laboratory) · 2019-09-11 · 7 citations

  preprintOpen accessSenior author

  Abstract Transposon mutagenesis is a widely used tool for carrying out forward genetic screens across systems, but in some cases it can be difficult to identify transposon insertion points after successful phenotypic screens. As an alternative to traditional methods, we report on the efficacy of using an Oxford Nanopore’s MinION to identify transposon insertions through whole genome sequencing. We also report experiments using CRISPR-Cas to selectively target regions of the genome where a transp…

  PublisherOA PDFDOI

• Genomic Background Governs Opposing Responses to Nalidixic Acid upon Megaplasmid Acquisition in <i>Pseudomonas</i>

  mSphere · 2021-02-23 · 5 citations

  articleOpen accessSenior author

  Numerous studies have demonstrated that gene transfer events (e.g., plasmid acquisition) can entail a variety of costs that arise as by-products of the incorporation of foreign DNA into established physiological and genetic systems. These costs can be ameliorated through evolutionary time by the occurrence of compensatory mutations, which stabilize the presence of a horizontally transferred region within the genome but which also may skew future adaptive possibilities for these lineages. Here, w…

  PublisherDOI

Frequent coauthors

• David A. Baltrus

  32 shared

• Brian A. Smith

  University of Minnesota

  13 shared

• Caitlin Smith

  University of Arizona

  11 shared

• Kevin Dougherty

  Foundation Medicine (United States)

  10 shared

• Joseph E. Spraker

  Paragon Genomics (United States)

  10 shared

• Kevin L. Hockett

  Pennsylvania State University

  9 shared

• Madison Mollico

  University of Arizona

  7 shared

• Courtney Leligdon

  University of Arizona

  5 shared

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