Michael H. Gelb
University of Washington · Chemistry
Active 1980–2026
Academic metrics are sourced from OpenAlex and public funding records; values may differ from Google Scholar.
About
Michael H. Gelb is a professor in the Department of Chemistry at the University of Washington, where he holds the Boris and Barbara L. Weinstein Endowed Chair in Chemistry. He earned his Ph.D. from Yale University in 1982 and has since established a distinguished career in the fields of analytical chemistry, catalysis, chemical biology, organic chemistry, and enzymology. His research focuses on understanding and applying biochemical processes, with notable contributions to newborn screening, for which he has received multiple awards including the American Public Health Laboratories Guthrie Award in 2022 and the American Chemical Society Repligen Award in Biological Chemistry in 2018. Gelb has been recognized for his significant contributions to the field, including the National MPS Society Legacy Award in 2024 and the Gustavus John Esselen Award from Harvard University in 2013. He is actively involved in teaching advanced courses such as Organic Chemistry and Chemical Biology, and his work has been acknowledged through various honors and fellowships, including being a Fellow of the American Association for the Advancement of Science since 2009.
Research topics
- Medicine
- Biology
- Genetics
- Pediatrics
- Internal medicine
- Physics
- Particle physics
- Chemistry
- Chromatography
- Nuclear physics
Selected publications
Progress of Theoretical and Experimental Physics · 2020 · 276 citations
In the original version of this manuscript, an error was introduced on pp352. '2.7nb:1.6nb' has been corrected to '2.4nb:1.3nb' in the current online and printed version. doi:10.1093/ptep/ptz106.
Design of intrinsically disordered region binding proteins
Science · 2025-07-17 · 71 citations
articleOpen accessIntrinsically disordered proteins and peptides play key roles in biology, but a lack of defined structures and high variability in sequence and conformational preferences have made targeting such systems challenging. We describe a general approach for designing proteins that bind intrinsically disordered protein regions in diverse extended conformations with side chains fitting into complementary binding pockets. We used the approach to design binders for 39 highly diverse unstructured targets,…
Orphanet Journal of Rare Diseases · 2020 · 64 citations
BACKGROUND: The necessity of early treatment for lysosomal storage diseases (LSDs) has triggered the development of newborn screening for LSDs in recent years. Here we report the first 70,000 newborns screened for Mucopolysaccharidosis (MPS) type 4A (Morquio syndrome) and other LSDs by an 8-plex assay including the original 4-plex LSD screening tandem mass spectrometry (MS/MS) assay for Pompe disease, Fabry disease, Gaucher disease, and MPS I disease. METHODS: The additional reaction for MPS II,…
The critical role of psychosine in screening, diagnosis, and monitoring of Krabbe disease
Genetics in Medicine · 2020 · 61 citations
Technical recommendations for analyzing oxylipins by liquid chromatography–mass spectrometry
Science Signaling · 2025-05-20 · 30 citations
reviewOpen accessSeveral oxylipins are potent lipid mediators that regulate diverse aspects of health and disease and whose quantitative analysis by liquid chromatography-mass spectrometry (LC-MS) presents substantial technical challenges. As members of the lipidomics community, we developed technical recommendations to ensure best practices when quantifying oxylipins by LC-MS.
Recent grants
NIH · $1.3M · 2005
NIH · $4.1M · 2007
Regulation and Function of Cytosolic Phospholipase A2
NIH · $3.0M · 1993–2014
Frequent coauthors
- 218 shared
M. Takizawa
- 213 shared
M. Iwasaki
- 206 shared
R. Mizuk
Laboratoire de Physique des 2 Infinis Irène Joliot-Curie
- 192 shared
V. Zhukova
- 191 shared
P. Krokovny
- 183 shared
P. Pakhlov
- 182 shared
E. Solovieva
- 181 shared
S. Nishida
Education
- 1985
Postdoctoral Fellow of the American Cancer Society, Biochemistry
Brandeis University
- 1982
PhD, Molecular Biophysics and Biochemistry
Yale University
Awards & honors
- National MPS Society Legacy Award, 2024
- Guthrie Award 2022
- Hannon Award for Excellence in Newborn Screening 2025
- Repligen Award in Biological Chemistry 2018
- Gustavus John Esselen Award, Harvard University 2013
Similar researchers at University of Washington
- Resume-aware match score
- Save to shortlist
- AI-drafted outreach
See your match with Michael H. Gelb
PhdFit ranks faculty by your research interests, methods, and publications — grounded in their actual work, not templates.
- Free to start
- No credit card
- 30-second signup