Megan B. Murray

About

Megan B. Murray is a faculty member serving as the Director at the Harvard Global Health Research Core. Her academic credentials include MD, ScD, and MPH. The page indicates her role within the team but does not provide specific details about her research focus, background, or key contributions.

Research topics

• Pathology
• Internal medicine
• Immunology
• Medicine
• Biology
• Environmental health
• Genetics
• Computational biology
• Demography
• Pediatrics

Selected publications

• The risk of tuberculosis in children after close exposure: a systematic review and individual-participant meta-analysis

  The Lancet · 2020 · 343 citations

  DOI

• Single-cell eQTL models reveal dynamic T cell state dependence of disease loci

  Nature · 2022 · 223 citations

  PublisherOA PDFDOI

• RISK6, a 6-gene transcriptomic signature of TB disease risk, diagnosis and treatment response

  Scientific Reports · 2020 · 169 citations

  Improved tuberculosis diagnostics and tools for monitoring treatment response are urgently needed. We developed a robust and simple, PCR-based host-blood transcriptomic signature, RISK6, for multiple applications: identifying individuals at risk of incident disease, as a screening test for subclinical or clinical tuberculosis, and for monitoring tuberculosis treatment. RISK6 utility was validated by blind prediction using quantitative real-time (qRT) PCR in seven independent cohorts. Prognostic…

  DOI

• The Impact of Vitamin A Deficiency on Tuberculosis Progression

  Clinical Infectious Diseases · 2022 · 19 citations

  Senior authorCorresponding

  BACKGROUND: Although previous studies have shown that vitamin A deficiency is associated with incident tuberculosis (TB) disease, the direction of the association has not been established. We investigated the impact of vitamin A deficiency on TB disease progression. METHODS: We conducted a longitudinal cohort study nested within a randomized clinical trial among HIV-infected patients in Haiti. We compared serial vitamin A levels in individuals who developed TB disease to controls matched on age,…

  PublisherOA PDFDOI

• Paired analysis of host and pathogen genomes identifies determinants of human tuberculosis

  Nature Communications · 2024-11-29 · 18 citations

  articleOpen access

  Abstract Infectious disease is the result of interactions between host and pathogen and can depend on genetic variations in both. We conduct a genome-to-genome study of paired human and Mycobacterium tuberculosis genomes from a cohort of 1556 tuberculosis patients in Lima, Peru. We identify an association between a human intronic variant (rs3130660, OR = 10.06, 95%CI: 4.87 − 20.77, P = 7.92 × 10 −8 ) in the FLOT1 gene and a subclavaluee of Mtb Lineage 2. In a human macrophage infection model, we…

  PublisherOA PDFDOI

Recent grants

• Bacterial Determinants of Treatment Response in Mycobacteria Tuberculosis

  NIH · $32.7M · 2019–2026

• Epidemiology of Infectious Diseases

  NIH · $4.8M · 1998–2026

• Identify the host genetic determinants of immune response and TB countrol

  NIH · $5.5M · 2015–2022

Frequent coauthors

• Brailey Sims

  Kinokuniya

  541 shared

• Robert Anderssen

  Kinokuniya

  541 shared

• G Lehrer

  Australian Mathematical Sciences Institute

  541 shared

• P Stacey

  498 shared

• J Cossey

  Australian Mathematical Sciences Institute

  498 shared

• G Ivanov

  New York University Press

  492 shared

• Oswald Jones

  Macquarie University

  437 shared

• Donald M. Taylor

  Marymount University

  429 shared

Labs

• Global Health Research CorePI

Education

• ScD

  Harvard School of Public Health

  2001

• MPH

  Harvard School of Public Health

  1997

• MD

  Harvard Medical School

  1990

Similar researchers at Harvard University

• Marc Lipsitchh-141
• James M. Robinsh-118
• Caroline Buckeeh-76